MiR-34 inhibits polycomb repressive complex 2 to modulate chaperone expression and promote healthy brain aging

MiR-34 inhibits polycomb repressive complex 2 to modulate chaperone expression and promote healthy brain aging

miR-34 is known to regulate age-related gene expression in the Drosophila brain, and miR-34 overexpression can attenuate neurodegeneration induced by polyQ-expanded proteins. Here, Kennerdell and colleagues show that miR-34 confers longevity and neuroprotection via an epigenetic regulator Polycomb R...

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Autores principales: Jason R. Kennerdell, Nan Liu, Nancy M. Bonini
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
Q
Acceso en línea:https://doaj.org/article/46b18f5ce1f94082bae17081ac9c2d7d
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spelling oai:doaj.org-article:46b18f5ce1f94082bae17081ac9c2d7d2021-12-02T17:31:30ZMiR-34 inhibits polycomb repressive complex 2 to modulate chaperone expression and promote healthy brain aging10.1038/s41467-018-06592-52041-1723https://doaj.org/article/46b18f5ce1f94082bae17081ac9c2d7d2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06592-5https://doaj.org/toc/2041-1723miR-34 is known to regulate age-related gene expression in the Drosophila brain, and miR-34 overexpression can attenuate neurodegeneration induced by polyQ-expanded proteins. Here, Kennerdell and colleagues show that miR-34 confers longevity and neuroprotection via an epigenetic regulator Polycomb Repressive Complex 2 and molecular chaperone expression.Jason R. KennerdellNan LiuNancy M. BoniniNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jason R. Kennerdell
Nan Liu
Nancy M. Bonini
MiR-34 inhibits polycomb repressive complex 2 to modulate chaperone expression and promote healthy brain aging
description miR-34 is known to regulate age-related gene expression in the Drosophila brain, and miR-34 overexpression can attenuate neurodegeneration induced by polyQ-expanded proteins. Here, Kennerdell and colleagues show that miR-34 confers longevity and neuroprotection via an epigenetic regulator Polycomb Repressive Complex 2 and molecular chaperone expression.
format article
author Jason R. Kennerdell
Nan Liu
Nancy M. Bonini
author_facet Jason R. Kennerdell
Nan Liu
Nancy M. Bonini
author_sort Jason R. Kennerdell
title MiR-34 inhibits polycomb repressive complex 2 to modulate chaperone expression and promote healthy brain aging
title_short MiR-34 inhibits polycomb repressive complex 2 to modulate chaperone expression and promote healthy brain aging
title_full MiR-34 inhibits polycomb repressive complex 2 to modulate chaperone expression and promote healthy brain aging
title_fullStr MiR-34 inhibits polycomb repressive complex 2 to modulate chaperone expression and promote healthy brain aging
title_full_unstemmed MiR-34 inhibits polycomb repressive complex 2 to modulate chaperone expression and promote healthy brain aging
title_sort mir-34 inhibits polycomb repressive complex 2 to modulate chaperone expression and promote healthy brain aging
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/46b18f5ce1f94082bae17081ac9c2d7d
work_keys_str_mv AT jasonrkennerdell mir34inhibitspolycombrepressivecomplex2tomodulatechaperoneexpressionandpromotehealthybrainaging
AT nanliu mir34inhibitspolycombrepressivecomplex2tomodulatechaperoneexpressionandpromotehealthybrainaging
AT nancymbonini mir34inhibitspolycombrepressivecomplex2tomodulatechaperoneexpressionandpromotehealthybrainaging
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