Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation

What keeps blood from clotting in homeostasis is a puzzle. Here, the authors suggest that lack of the enzyme disulfide isomerase (PDI) in the blood is key, and show that PDI is secreted only after vascular injury to act on substrates that include vitronectin, affecting its binding to αVβ3 and αIIbβ3...

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Autores principales: Sheryl R. Bowley, Chao Fang, Glenn Merrill-Skoloff, Barbara C. Furie, Bruce Furie
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/46b7214a18e6426fb3abcf41ea49708f
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