Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation

What keeps blood from clotting in homeostasis is a puzzle. Here, the authors suggest that lack of the enzyme disulfide isomerase (PDI) in the blood is key, and show that PDI is secreted only after vascular injury to act on substrates that include vitronectin, affecting its binding to αVβ3 and αIIbβ3...

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Autores principales:	Sheryl R. Bowley, Chao Fang, Glenn Merrill-Skoloff, Barbara C. Furie, Bruce Furie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/46b7214a18e6426fb3abcf41ea49708f
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spelling	oai:doaj.org-article:46b7214a18e6426fb3abcf41ea49708f2021-12-02T14:42:28ZProtein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation10.1038/ncomms141512041-1723https://doaj.org/article/46b7214a18e6426fb3abcf41ea49708f2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14151https://doaj.org/toc/2041-1723What keeps blood from clotting in homeostasis is a puzzle. Here, the authors suggest that lack of the enzyme disulfide isomerase (PDI) in the blood is key, and show that PDI is secreted only after vascular injury to act on substrates that include vitronectin, affecting its binding to αVβ3 and αIIbβ3 integrins and enabling thrombus formation.Sheryl R. BowleyChao FangGlenn Merrill-SkoloffBarbara C. FurieBruce FurieNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sheryl R. Bowley Chao Fang Glenn Merrill-Skoloff Barbara C. Furie Bruce Furie Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation
description	What keeps blood from clotting in homeostasis is a puzzle. Here, the authors suggest that lack of the enzyme disulfide isomerase (PDI) in the blood is key, and show that PDI is secreted only after vascular injury to act on substrates that include vitronectin, affecting its binding to αVβ3 and αIIbβ3 integrins and enabling thrombus formation.
format	article
author	Sheryl R. Bowley Chao Fang Glenn Merrill-Skoloff Barbara C. Furie Bruce Furie
author_facet	Sheryl R. Bowley Chao Fang Glenn Merrill-Skoloff Barbara C. Furie Bruce Furie
author_sort	Sheryl R. Bowley
title	Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation
title_short	Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation
title_full	Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation
title_fullStr	Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation
title_full_unstemmed	Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation
title_sort	protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/46b7214a18e6426fb3abcf41ea49708f
work_keys_str_mv	AT sherylrbowley proteindisulfideisomerasesecretionfollowingvascularinjuryinitiatesaregulatorypathwayforthrombusformation AT chaofang proteindisulfideisomerasesecretionfollowingvascularinjuryinitiatesaregulatorypathwayforthrombusformation AT glennmerrillskoloff proteindisulfideisomerasesecretionfollowingvascularinjuryinitiatesaregulatorypathwayforthrombusformation AT barbaracfurie proteindisulfideisomerasesecretionfollowingvascularinjuryinitiatesaregulatorypathwayforthrombusformation AT brucefurie proteindisulfideisomerasesecretionfollowingvascularinjuryinitiatesaregulatorypathwayforthrombusformation
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Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation

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