Bach2–Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop

Bach2 limits T cell effector functions. Here the authors show that Bach2–Batf complex antagonizes the recruitment of the Batf–Irf4 complex to AP-1 motifs and suppresses Th2 cytokine production, and describe mechanisms of negative feedback by which Bach2 restricts Baft-mediated Th2 response.

Guardado en:

Detalles Bibliográficos
Autores principales:	Makoto Kuwahara, Wataru Ise, Mizuki Ochi, Junpei Suzuki, Kohei Kometani, Saho Maruyama, Maya Izumoto, Akira Matsumoto, Nobuaki Takemori, Ayako Takemori, Kenta Shinoda, Toshinori Nakayama, Osamu Ohara, Masaki Yasukawa, Tatsuya Sawasaki, Tomohiro Kurosaki, Masakatsu Yamashita
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/46c2c5dacb5943f286af54fec57af3ac
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:46c2c5dacb5943f286af54fec57af3ac
record_format	dspace
spelling	oai:doaj.org-article:46c2c5dacb5943f286af54fec57af3ac2021-12-02T17:31:31ZBach2–Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop10.1038/ncomms125962041-1723https://doaj.org/article/46c2c5dacb5943f286af54fec57af3ac2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12596https://doaj.org/toc/2041-1723Bach2 limits T cell effector functions. Here the authors show that Bach2–Batf complex antagonizes the recruitment of the Batf–Irf4 complex to AP-1 motifs and suppresses Th2 cytokine production, and describe mechanisms of negative feedback by which Bach2 restricts Baft-mediated Th2 response.Makoto KuwaharaWataru IseMizuki OchiJunpei SuzukiKohei KometaniSaho MaruyamaMaya IzumotoAkira MatsumotoNobuaki TakemoriAyako TakemoriKenta ShinodaToshinori NakayamaOsamu OharaMasaki YasukawaTatsuya SawasakiTomohiro KurosakiMasakatsu YamashitaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Makoto Kuwahara Wataru Ise Mizuki Ochi Junpei Suzuki Kohei Kometani Saho Maruyama Maya Izumoto Akira Matsumoto Nobuaki Takemori Ayako Takemori Kenta Shinoda Toshinori Nakayama Osamu Ohara Masaki Yasukawa Tatsuya Sawasaki Tomohiro Kurosaki Masakatsu Yamashita Bach2–Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop
description	Bach2 limits T cell effector functions. Here the authors show that Bach2–Batf complex antagonizes the recruitment of the Batf–Irf4 complex to AP-1 motifs and suppresses Th2 cytokine production, and describe mechanisms of negative feedback by which Bach2 restricts Baft-mediated Th2 response.
format	article
author	Makoto Kuwahara Wataru Ise Mizuki Ochi Junpei Suzuki Kohei Kometani Saho Maruyama Maya Izumoto Akira Matsumoto Nobuaki Takemori Ayako Takemori Kenta Shinoda Toshinori Nakayama Osamu Ohara Masaki Yasukawa Tatsuya Sawasaki Tomohiro Kurosaki Masakatsu Yamashita
author_facet	Makoto Kuwahara Wataru Ise Mizuki Ochi Junpei Suzuki Kohei Kometani Saho Maruyama Maya Izumoto Akira Matsumoto Nobuaki Takemori Ayako Takemori Kenta Shinoda Toshinori Nakayama Osamu Ohara Masaki Yasukawa Tatsuya Sawasaki Tomohiro Kurosaki Masakatsu Yamashita
author_sort	Makoto Kuwahara
title	Bach2–Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop
title_short	Bach2–Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop
title_full	Bach2–Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop
title_fullStr	Bach2–Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop
title_full_unstemmed	Bach2–Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop
title_sort	bach2–batf interactions control th2-type immune response by regulating the il-4 amplification loop
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/46c2c5dacb5943f286af54fec57af3ac
work_keys_str_mv	AT makotokuwahara bach2batfinteractionscontrolth2typeimmuneresponsebyregulatingtheil4amplificationloop AT wataruise bach2batfinteractionscontrolth2typeimmuneresponsebyregulatingtheil4amplificationloop AT mizukiochi bach2batfinteractionscontrolth2typeimmuneresponsebyregulatingtheil4amplificationloop AT junpeisuzuki bach2batfinteractionscontrolth2typeimmuneresponsebyregulatingtheil4amplificationloop AT koheikometani bach2batfinteractionscontrolth2typeimmuneresponsebyregulatingtheil4amplificationloop AT sahomaruyama bach2batfinteractionscontrolth2typeimmuneresponsebyregulatingtheil4amplificationloop AT mayaizumoto bach2batfinteractionscontrolth2typeimmuneresponsebyregulatingtheil4amplificationloop AT akiramatsumoto bach2batfinteractionscontrolth2typeimmuneresponsebyregulatingtheil4amplificationloop AT nobuakitakemori bach2batfinteractionscontrolth2typeimmuneresponsebyregulatingtheil4amplificationloop AT ayakotakemori bach2batfinteractionscontrolth2typeimmuneresponsebyregulatingtheil4amplificationloop AT kentashinoda bach2batfinteractionscontrolth2typeimmuneresponsebyregulatingtheil4amplificationloop AT toshinorinakayama bach2batfinteractionscontrolth2typeimmuneresponsebyregulatingtheil4amplificationloop AT osamuohara bach2batfinteractionscontrolth2typeimmuneresponsebyregulatingtheil4amplificationloop AT masakiyasukawa bach2batfinteractionscontrolth2typeimmuneresponsebyregulatingtheil4amplificationloop AT tatsuyasawasaki bach2batfinteractionscontrolth2typeimmuneresponsebyregulatingtheil4amplificationloop AT tomohirokurosaki bach2batfinteractionscontrolth2typeimmuneresponsebyregulatingtheil4amplificationloop AT masakatsuyamashita bach2batfinteractionscontrolth2typeimmuneresponsebyregulatingtheil4amplificationloop
_version_	1718380549587861504

Bach2–Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop

Ejemplares similares