Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

Activation of DNA damage response induces the acquisition of senescence-associated secretory phenotype (SASP) in senescent cells, but precise mechanisms remain unclear. Here, the authors show that the cytoplasmic accumulation of nuclear DNA activated cytoplasmic DNA sensors to provoke SASP.

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Bibliographic Details
Main Authors:	Akiko Takahashi, Tze Mun Loo, Ryo Okada, Fumitaka Kamachi, Yoshihiro Watanabe, Masahiro Wakita, Sugiko Watanabe, Shimpei Kawamoto, Kenichi Miyata, Glen N. Barber, Naoko Ohtani, Eiji Hara
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/46c6acdb2be24972a182358d788f7bc6
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spelling	oai:doaj.org-article:46c6acdb2be24972a182358d788f7bc62021-12-02T14:40:30ZDownregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells10.1038/s41467-018-03555-82041-1723https://doaj.org/article/46c6acdb2be24972a182358d788f7bc62018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03555-8https://doaj.org/toc/2041-1723Activation of DNA damage response induces the acquisition of senescence-associated secretory phenotype (SASP) in senescent cells, but precise mechanisms remain unclear. Here, the authors show that the cytoplasmic accumulation of nuclear DNA activated cytoplasmic DNA sensors to provoke SASP.Akiko TakahashiTze Mun LooRyo OkadaFumitaka KamachiYoshihiro WatanabeMasahiro WakitaSugiko WatanabeShimpei KawamotoKenichi MiyataGlen N. BarberNaoko OhtaniEiji HaraNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Akiko Takahashi Tze Mun Loo Ryo Okada Fumitaka Kamachi Yoshihiro Watanabe Masahiro Wakita Sugiko Watanabe Shimpei Kawamoto Kenichi Miyata Glen N. Barber Naoko Ohtani Eiji Hara Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells
description	Activation of DNA damage response induces the acquisition of senescence-associated secretory phenotype (SASP) in senescent cells, but precise mechanisms remain unclear. Here, the authors show that the cytoplasmic accumulation of nuclear DNA activated cytoplasmic DNA sensors to provoke SASP.
format	article
author	Akiko Takahashi Tze Mun Loo Ryo Okada Fumitaka Kamachi Yoshihiro Watanabe Masahiro Wakita Sugiko Watanabe Shimpei Kawamoto Kenichi Miyata Glen N. Barber Naoko Ohtani Eiji Hara
author_facet	Akiko Takahashi Tze Mun Loo Ryo Okada Fumitaka Kamachi Yoshihiro Watanabe Masahiro Wakita Sugiko Watanabe Shimpei Kawamoto Kenichi Miyata Glen N. Barber Naoko Ohtani Eiji Hara
author_sort	Akiko Takahashi
title	Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells
title_short	Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells
title_full	Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells
title_fullStr	Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells
title_full_unstemmed	Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells
title_sort	downregulation of cytoplasmic dnases is implicated in cytoplasmic dna accumulation and sasp in senescent cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/46c6acdb2be24972a182358d788f7bc6
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Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

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