Mucoadhesive, Thermoreversible Hydrogel, Containing Tetracaine-Loaded Nanostructured Lipid Carriers for Topical, Intranasal Needle-Free Anesthesia

Mucoadhesive, Thermoreversible Hydrogel, Containing Tetracaine-Loaded Nanostructured Lipid Carriers for Topical, Intranasal Needle-Free Anesthesia

Recent advances have been reported for needle-free local anesthesia in maxillary teeth by administering a nasal spray of tetracaine (TTC) and oxymetazoline, without causing pain, fear, and stress. This work aimed to assess whether a TTC-loaded hybrid system could reduce cytotoxicity, promote sustain...

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Autores principales: Giovana Maria Fioramonti Calixto, Bruno Vilela Muniz, Simone R. Castro, Jaiza Samara Macena de Araujo, Klinger de Souza Amorim, Lígia N. M. Ribeiro, Luiz Eduardo Nunes Ferreira, Daniele Ribeiro de Araújo, Eneida de Paula, Michelle Franz-Montan
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
nanostructured lipid carriers
thermoreversible hydrogel
nasal administration
mucoadhesion
topical anesthesia
tetracaine
Pharmacy and materia medica
RS1-441
Acceso en línea:https://doaj.org/article/47407dbe31b5403ca40d04eb1642c9de
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https://doaj.org/article/47407dbe31b5403ca40d04eb1642c9de

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