Neutralizing the pathological effects of extracellular histones with small polyanions

Histones, proteins that bind DNA, are toxic for pathogens outside cells but can also cause multi-organ damage as seen in sepsis. Here the authors develop small negatively charged molecules that can be used as histone antidotes, and show that they improve the phenotype in mouse models with histone-re...

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Autores principales:	Connor H. O’ Meara, Lucy A. Coupland, Farzaneh Kordbacheh, Benjamin J. C. Quah, Chih-Wei Chang, David A. Simon Davis, Anna Bezos, Anna M. Browne, Craig Freeman, Dillon J. Hammill, Pradeep Chopra, Gergely Pipa, Paul D. Madge, Esther Gallant, Courtney Segovis, Angela F. Dulhunty, Leonard F. Arnolda, Imogen Mitchell, Levon M. Khachigian, Ross W. Stephens, Mark von Itzstein, Christopher R. Parish
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/47652de3a653433fb4ea511fb90437ea
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spelling	oai:doaj.org-article:47652de3a653433fb4ea511fb90437ea2021-12-02T14:16:24ZNeutralizing the pathological effects of extracellular histones with small polyanions10.1038/s41467-020-20231-y2041-1723https://doaj.org/article/47652de3a653433fb4ea511fb90437ea2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20231-yhttps://doaj.org/toc/2041-1723Histones, proteins that bind DNA, are toxic for pathogens outside cells but can also cause multi-organ damage as seen in sepsis. Here the authors develop small negatively charged molecules that can be used as histone antidotes, and show that they improve the phenotype in mouse models with histone-related pathologies.Connor H. O’ MearaLucy A. CouplandFarzaneh KordbachehBenjamin J. C. QuahChih-Wei ChangDavid A. Simon DavisAnna BezosAnna M. BrowneCraig FreemanDillon J. HammillPradeep ChopraGergely PipaPaul D. MadgeEsther GallantCourtney SegovisAngela F. DulhuntyLeonard F. ArnoldaImogen MitchellLevon M. KhachigianRoss W. StephensMark von ItzsteinChristopher R. ParishNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Connor H. O’ Meara Lucy A. Coupland Farzaneh Kordbacheh Benjamin J. C. Quah Chih-Wei Chang David A. Simon Davis Anna Bezos Anna M. Browne Craig Freeman Dillon J. Hammill Pradeep Chopra Gergely Pipa Paul D. Madge Esther Gallant Courtney Segovis Angela F. Dulhunty Leonard F. Arnolda Imogen Mitchell Levon M. Khachigian Ross W. Stephens Mark von Itzstein Christopher R. Parish Neutralizing the pathological effects of extracellular histones with small polyanions
description	Histones, proteins that bind DNA, are toxic for pathogens outside cells but can also cause multi-organ damage as seen in sepsis. Here the authors develop small negatively charged molecules that can be used as histone antidotes, and show that they improve the phenotype in mouse models with histone-related pathologies.
format	article
author	Connor H. O’ Meara Lucy A. Coupland Farzaneh Kordbacheh Benjamin J. C. Quah Chih-Wei Chang David A. Simon Davis Anna Bezos Anna M. Browne Craig Freeman Dillon J. Hammill Pradeep Chopra Gergely Pipa Paul D. Madge Esther Gallant Courtney Segovis Angela F. Dulhunty Leonard F. Arnolda Imogen Mitchell Levon M. Khachigian Ross W. Stephens Mark von Itzstein Christopher R. Parish
author_facet	Connor H. O’ Meara Lucy A. Coupland Farzaneh Kordbacheh Benjamin J. C. Quah Chih-Wei Chang David A. Simon Davis Anna Bezos Anna M. Browne Craig Freeman Dillon J. Hammill Pradeep Chopra Gergely Pipa Paul D. Madge Esther Gallant Courtney Segovis Angela F. Dulhunty Leonard F. Arnolda Imogen Mitchell Levon M. Khachigian Ross W. Stephens Mark von Itzstein Christopher R. Parish
author_sort	Connor H. O’ Meara
title	Neutralizing the pathological effects of extracellular histones with small polyanions
title_short	Neutralizing the pathological effects of extracellular histones with small polyanions
title_full	Neutralizing the pathological effects of extracellular histones with small polyanions
title_fullStr	Neutralizing the pathological effects of extracellular histones with small polyanions
title_full_unstemmed	Neutralizing the pathological effects of extracellular histones with small polyanions
title_sort	neutralizing the pathological effects of extracellular histones with small polyanions
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/47652de3a653433fb4ea511fb90437ea
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Neutralizing the pathological effects of extracellular histones with small polyanions

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