PRKCSH contributes to tumorigenesis by selective boosting of IRE1 signaling pathway
Cancer cells utilise the unfolded protein response (UPR) to adapt to environmental and ER stress. Here, the authors show that the glycosidase II beta subunit, PRKSCH, protects cancer cells from ER stress, by interacting with IRE1α and activating the IRE1α-XBP1 branch of the UPR.
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2019
|
| Subjects: | |
| Online Access: | https://doaj.org/article/47943695204246b59ebfa2cd837997f4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|