PRKCSH contributes to tumorigenesis by selective boosting of IRE1 signaling pathway

Cancer cells utilise the unfolded protein response (UPR) to adapt to environmental and ER stress. Here, the authors show that the glycosidase II beta subunit, PRKSCH, protects cancer cells from ER stress, by interacting with IRE1α and activating the IRE1α-XBP1 branch of the UPR.

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Autores principales:	Gu-Choul Shin, Sung Ung Moon, Hong Seok Kang, Hyo-Sun Choi, Hee Dong Han, Kyun-Hwan Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/47943695204246b59ebfa2cd837997f4
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spelling	oai:doaj.org-article:47943695204246b59ebfa2cd837997f42021-12-02T14:35:55ZPRKCSH contributes to tumorigenesis by selective boosting of IRE1 signaling pathway10.1038/s41467-019-11019-w2041-1723https://doaj.org/article/47943695204246b59ebfa2cd837997f42019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11019-whttps://doaj.org/toc/2041-1723Cancer cells utilise the unfolded protein response (UPR) to adapt to environmental and ER stress. Here, the authors show that the glycosidase II beta subunit, PRKSCH, protects cancer cells from ER stress, by interacting with IRE1α and activating the IRE1α-XBP1 branch of the UPR.Gu-Choul ShinSung Ung MoonHong Seok KangHyo-Sun ChoiHee Dong HanKyun-Hwan KimNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gu-Choul Shin Sung Ung Moon Hong Seok Kang Hyo-Sun Choi Hee Dong Han Kyun-Hwan Kim PRKCSH contributes to tumorigenesis by selective boosting of IRE1 signaling pathway
description	Cancer cells utilise the unfolded protein response (UPR) to adapt to environmental and ER stress. Here, the authors show that the glycosidase II beta subunit, PRKSCH, protects cancer cells from ER stress, by interacting with IRE1α and activating the IRE1α-XBP1 branch of the UPR.
format	article
author	Gu-Choul Shin Sung Ung Moon Hong Seok Kang Hyo-Sun Choi Hee Dong Han Kyun-Hwan Kim
author_facet	Gu-Choul Shin Sung Ung Moon Hong Seok Kang Hyo-Sun Choi Hee Dong Han Kyun-Hwan Kim
author_sort	Gu-Choul Shin
title	PRKCSH contributes to tumorigenesis by selective boosting of IRE1 signaling pathway
title_short	PRKCSH contributes to tumorigenesis by selective boosting of IRE1 signaling pathway
title_full	PRKCSH contributes to tumorigenesis by selective boosting of IRE1 signaling pathway
title_fullStr	PRKCSH contributes to tumorigenesis by selective boosting of IRE1 signaling pathway
title_full_unstemmed	PRKCSH contributes to tumorigenesis by selective boosting of IRE1 signaling pathway
title_sort	prkcsh contributes to tumorigenesis by selective boosting of ire1 signaling pathway
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/47943695204246b59ebfa2cd837997f4
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_version_	1718391002955251712

PRKCSH contributes to tumorigenesis by selective boosting of IRE1 signaling pathway

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