Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter

Molecular details of how antidepressant drugs bind to the human serotonin transporter are not currently clear. Here, the authors introduce photo-cross-linkers into the protein and map the binding site of several antidepressants.

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Autores principales: Hafsteinn Rannversson, Jacob Andersen, Lena Sørensen, Benny Bang-Andersen, Minyoung Park, Thomas Huber, Thomas P. Sakmar, Kristian Strømgaard
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/47a0fbeee8d544c7b6ee9bb029f13198
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