Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter

Molecular details of how antidepressant drugs bind to the human serotonin transporter are not currently clear. Here, the authors introduce photo-cross-linkers into the protein and map the binding site of several antidepressants.

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Autores principales:	Hafsteinn Rannversson, Jacob Andersen, Lena Sørensen, Benny Bang-Andersen, Minyoung Park, Thomas Huber, Thomas P. Sakmar, Kristian Strømgaard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/47a0fbeee8d544c7b6ee9bb029f13198
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spelling	oai:doaj.org-article:47a0fbeee8d544c7b6ee9bb029f131982021-12-02T15:34:10ZGenetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter10.1038/ncomms112612041-1723https://doaj.org/article/47a0fbeee8d544c7b6ee9bb029f131982016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11261https://doaj.org/toc/2041-1723Molecular details of how antidepressant drugs bind to the human serotonin transporter are not currently clear. Here, the authors introduce photo-cross-linkers into the protein and map the binding site of several antidepressants.Hafsteinn RannverssonJacob AndersenLena SørensenBenny Bang-AndersenMinyoung ParkThomas HuberThomas P. SakmarKristian StrømgaardNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hafsteinn Rannversson Jacob Andersen Lena Sørensen Benny Bang-Andersen Minyoung Park Thomas Huber Thomas P. Sakmar Kristian Strømgaard Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter
description	Molecular details of how antidepressant drugs bind to the human serotonin transporter are not currently clear. Here, the authors introduce photo-cross-linkers into the protein and map the binding site of several antidepressants.
format	article
author	Hafsteinn Rannversson Jacob Andersen Lena Sørensen Benny Bang-Andersen Minyoung Park Thomas Huber Thomas P. Sakmar Kristian Strømgaard
author_facet	Hafsteinn Rannversson Jacob Andersen Lena Sørensen Benny Bang-Andersen Minyoung Park Thomas Huber Thomas P. Sakmar Kristian Strømgaard
author_sort	Hafsteinn Rannversson
title	Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter
title_short	Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter
title_full	Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter
title_fullStr	Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter
title_full_unstemmed	Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter
title_sort	genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/47a0fbeee8d544c7b6ee9bb029f13198
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Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter

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