APOE ε2 is associated with increased tau pathology in primary tauopathy

APOE ε2 is associated with increased tau pathology in primary tauopathy

The APOE ε4 allele is a strong genetic risk factor for Alzheimer’s disease, whereas the APOE ε2 allele is protective. Here the authors show that mice expressing the human APOE ε2/ε2 genotype have increased tau pathology and related behavioral deficits; they also find that the APOE ε2 allele is assoc...

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Auteurs principaux: Na Zhao, Chia-Chen Liu, Alexandra J. Van Ingelgom, Cynthia Linares, Aishe Kurti, Joshua A. Knight, Michael G. Heckman, Nancy N. Diehl, Mitsuru Shinohara, Yuka A. Martens, Olivia N. Attrebi, Leonard Petrucelli, John D. Fryer, Zbigniew K. Wszolek, Neill R. Graff-Radford, Richard J. Caselli, Monica Y. Sanchez-Contreras, Rosa Rademakers, Melissa E. Murray, Shunsuke Koga, Dennis W. Dickson, Owen A. Ross, Guojun Bu
Format: article
Langue:EN
Publié: Nature Portfolio 2018
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/47acaeff9b2f4fb58aa35f26dc4d2d72
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Internet

https://doaj.org/article/47acaeff9b2f4fb58aa35f26dc4d2d72

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