APOE ε2 is associated with increased tau pathology in primary tauopathy
The APOE ε4 allele is a strong genetic risk factor for Alzheimer’s disease, whereas the APOE ε2 allele is protective. Here the authors show that mice expressing the human APOE ε2/ε2 genotype have increased tau pathology and related behavioral deficits; they also find that the APOE ε2 allele is assoc...
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Nature Portfolio
2018
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oai:doaj.org-article:47acaeff9b2f4fb58aa35f26dc4d2d722021-12-02T16:56:38ZAPOE ε2 is associated with increased tau pathology in primary tauopathy10.1038/s41467-018-06783-02041-1723https://doaj.org/article/47acaeff9b2f4fb58aa35f26dc4d2d722018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06783-0https://doaj.org/toc/2041-1723The APOE ε4 allele is a strong genetic risk factor for Alzheimer’s disease, whereas the APOE ε2 allele is protective. Here the authors show that mice expressing the human APOE ε2/ε2 genotype have increased tau pathology and related behavioral deficits; they also find that the APOE ε2 allele is associated with an increased burden of tau pathology in postmortem human brains with progressive supranuclear palsy.Na ZhaoChia-Chen LiuAlexandra J. Van IngelgomCynthia LinaresAishe KurtiJoshua A. KnightMichael G. HeckmanNancy N. DiehlMitsuru ShinoharaYuka A. MartensOlivia N. AttrebiLeonard PetrucelliJohn D. FryerZbigniew K. WszolekNeill R. Graff-RadfordRichard J. CaselliMonica Y. Sanchez-ContrerasRosa RademakersMelissa E. MurrayShunsuke KogaDennis W. DicksonOwen A. RossGuojun BuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018) |
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EN |
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Science Q |
| spellingShingle |
Science Q Na Zhao Chia-Chen Liu Alexandra J. Van Ingelgom Cynthia Linares Aishe Kurti Joshua A. Knight Michael G. Heckman Nancy N. Diehl Mitsuru Shinohara Yuka A. Martens Olivia N. Attrebi Leonard Petrucelli John D. Fryer Zbigniew K. Wszolek Neill R. Graff-Radford Richard J. Caselli Monica Y. Sanchez-Contreras Rosa Rademakers Melissa E. Murray Shunsuke Koga Dennis W. Dickson Owen A. Ross Guojun Bu APOE ε2 is associated with increased tau pathology in primary tauopathy |
| description |
The APOE ε4 allele is a strong genetic risk factor for Alzheimer’s disease, whereas the APOE ε2 allele is protective. Here the authors show that mice expressing the human APOE ε2/ε2 genotype have increased tau pathology and related behavioral deficits; they also find that the APOE ε2 allele is associated with an increased burden of tau pathology in postmortem human brains with progressive supranuclear palsy. |
| format |
article |
| author |
Na Zhao Chia-Chen Liu Alexandra J. Van Ingelgom Cynthia Linares Aishe Kurti Joshua A. Knight Michael G. Heckman Nancy N. Diehl Mitsuru Shinohara Yuka A. Martens Olivia N. Attrebi Leonard Petrucelli John D. Fryer Zbigniew K. Wszolek Neill R. Graff-Radford Richard J. Caselli Monica Y. Sanchez-Contreras Rosa Rademakers Melissa E. Murray Shunsuke Koga Dennis W. Dickson Owen A. Ross Guojun Bu |
| author_facet |
Na Zhao Chia-Chen Liu Alexandra J. Van Ingelgom Cynthia Linares Aishe Kurti Joshua A. Knight Michael G. Heckman Nancy N. Diehl Mitsuru Shinohara Yuka A. Martens Olivia N. Attrebi Leonard Petrucelli John D. Fryer Zbigniew K. Wszolek Neill R. Graff-Radford Richard J. Caselli Monica Y. Sanchez-Contreras Rosa Rademakers Melissa E. Murray Shunsuke Koga Dennis W. Dickson Owen A. Ross Guojun Bu |
| author_sort |
Na Zhao |
| title |
APOE ε2 is associated with increased tau pathology in primary tauopathy |
| title_short |
APOE ε2 is associated with increased tau pathology in primary tauopathy |
| title_full |
APOE ε2 is associated with increased tau pathology in primary tauopathy |
| title_fullStr |
APOE ε2 is associated with increased tau pathology in primary tauopathy |
| title_full_unstemmed |
APOE ε2 is associated with increased tau pathology in primary tauopathy |
| title_sort |
apoe ε2 is associated with increased tau pathology in primary tauopathy |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/47acaeff9b2f4fb58aa35f26dc4d2d72 |
| work_keys_str_mv |
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