APOE ε2 is associated with increased tau pathology in primary tauopathy

APOE ε2 is associated with increased tau pathology in primary tauopathy

The APOE ε4 allele is a strong genetic risk factor for Alzheimer’s disease, whereas the APOE ε2 allele is protective. Here the authors show that mice expressing the human APOE ε2/ε2 genotype have increased tau pathology and related behavioral deficits; they also find that the APOE ε2 allele is assoc...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Na Zhao, Chia-Chen Liu, Alexandra J. Van Ingelgom, Cynthia Linares, Aishe Kurti, Joshua A. Knight, Michael G. Heckman, Nancy N. Diehl, Mitsuru Shinohara, Yuka A. Martens, Olivia N. Attrebi, Leonard Petrucelli, John D. Fryer, Zbigniew K. Wszolek, Neill R. Graff-Radford, Richard J. Caselli, Monica Y. Sanchez-Contreras, Rosa Rademakers, Melissa E. Murray, Shunsuke Koga, Dennis W. Dickson, Owen A. Ross, Guojun Bu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/47acaeff9b2f4fb58aa35f26dc4d2d72
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Ejemplares similares