Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary
Little is known about the genetics of sclerosing stromal tumor of the ovary, a rare type of sex cord-stromal tumor. Here, the authors use sequencing strategies to show that in a cohort of 26 tumor samples 65% carry a FHL2-GLI2 fusion gene and demonstrate in vitro that the fusion gene has oncogenic p...
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Nature Portfolio
2020
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oai:doaj.org-article:47b2a974b2b14385a7cca2142adfd91e2021-12-02T14:40:38ZIdentification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary10.1038/s41467-019-13806-x2041-1723https://doaj.org/article/47b2a974b2b14385a7cca2142adfd91e2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13806-xhttps://doaj.org/toc/2041-1723Little is known about the genetics of sclerosing stromal tumor of the ovary, a rare type of sex cord-stromal tumor. Here, the authors use sequencing strategies to show that in a cohort of 26 tumor samples 65% carry a FHL2-GLI2 fusion gene and demonstrate in vitro that the fusion gene has oncogenic properties.Sarah H. KimArnaud Da Cruz PaulaThais BasiliHiginio DopesoRui BiFresia ParejaEdaise M. da SilvaRodrigo Gularte-MéridaZhen SunSho FujisawaCaitlin G. SmithLorenzo FerrandoAna Paula Martins SebastiãoYonina BykovAnqi LiCatarina SilveiraCharles W. AshleyAnthe StylianouPier SelenicaWesley R. SamoreAchim A. JungbluthDmitriy ZamarinNadeem R. Abu-RustumKristian HelinRobert A. SoslowJorge S. Reis-FilhoEsther OlivaBritta WeigeltNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020) |
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Science Q Sarah H. Kim Arnaud Da Cruz Paula Thais Basili Higinio Dopeso Rui Bi Fresia Pareja Edaise M. da Silva Rodrigo Gularte-Mérida Zhen Sun Sho Fujisawa Caitlin G. Smith Lorenzo Ferrando Ana Paula Martins Sebastião Yonina Bykov Anqi Li Catarina Silveira Charles W. Ashley Anthe Stylianou Pier Selenica Wesley R. Samore Achim A. Jungbluth Dmitriy Zamarin Nadeem R. Abu-Rustum Kristian Helin Robert A. Soslow Jorge S. Reis-Filho Esther Oliva Britta Weigelt Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary |
| description |
Little is known about the genetics of sclerosing stromal tumor of the ovary, a rare type of sex cord-stromal tumor. Here, the authors use sequencing strategies to show that in a cohort of 26 tumor samples 65% carry a FHL2-GLI2 fusion gene and demonstrate in vitro that the fusion gene has oncogenic properties. |
| format |
article |
| author |
Sarah H. Kim Arnaud Da Cruz Paula Thais Basili Higinio Dopeso Rui Bi Fresia Pareja Edaise M. da Silva Rodrigo Gularte-Mérida Zhen Sun Sho Fujisawa Caitlin G. Smith Lorenzo Ferrando Ana Paula Martins Sebastião Yonina Bykov Anqi Li Catarina Silveira Charles W. Ashley Anthe Stylianou Pier Selenica Wesley R. Samore Achim A. Jungbluth Dmitriy Zamarin Nadeem R. Abu-Rustum Kristian Helin Robert A. Soslow Jorge S. Reis-Filho Esther Oliva Britta Weigelt |
| author_facet |
Sarah H. Kim Arnaud Da Cruz Paula Thais Basili Higinio Dopeso Rui Bi Fresia Pareja Edaise M. da Silva Rodrigo Gularte-Mérida Zhen Sun Sho Fujisawa Caitlin G. Smith Lorenzo Ferrando Ana Paula Martins Sebastião Yonina Bykov Anqi Li Catarina Silveira Charles W. Ashley Anthe Stylianou Pier Selenica Wesley R. Samore Achim A. Jungbluth Dmitriy Zamarin Nadeem R. Abu-Rustum Kristian Helin Robert A. Soslow Jorge S. Reis-Filho Esther Oliva Britta Weigelt |
| author_sort |
Sarah H. Kim |
| title |
Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary |
| title_short |
Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary |
| title_full |
Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary |
| title_fullStr |
Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary |
| title_full_unstemmed |
Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary |
| title_sort |
identification of recurrent fhl2-gli2 oncogenic fusion in sclerosing stromal tumors of the ovary |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/47b2a974b2b14385a7cca2142adfd91e |
| work_keys_str_mv |
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