Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization
Stüber et. al. show that receptor tyrosine kinase signaling can be neutralized through intermolecular, biparatopic bipDARPin crosslinking that locks down the bipDARPin-HER2 complexes. This affects the spatiotemporal organization and dynamics of HER2 in the plasma membrane.
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| Autores principales: | , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/47e73f2b585647239c63400329c551bf |
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| Sumario: | Stüber et. al. show that receptor tyrosine kinase signaling can be neutralized through intermolecular, biparatopic bipDARPin crosslinking that locks down the bipDARPin-HER2 complexes. This affects the spatiotemporal organization and dynamics of HER2 in the plasma membrane. |
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