Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization

Stüber et. al. show that receptor tyrosine kinase signaling can be neutralized through intermolecular, biparatopic bipDARPin crosslinking that locks down the bipDARPin-HER2 complexes. This affects the spatiotemporal organization and dynamics of HER2 in the plasma membrane.

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Autores principales:	Jakob C. Stüber, Christian P. Richter, Junel Sotolongo Bellón, Martin Schwill, Iwo König, Benjamin Schuler, Jacob Piehler, Andreas Plückthun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/47e73f2b585647239c63400329c551bf
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spelling	oai:doaj.org-article:47e73f2b585647239c63400329c551bf2021-12-02T18:02:53ZApoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization10.1038/s42003-021-02253-42399-3642https://doaj.org/article/47e73f2b585647239c63400329c551bf2021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02253-4https://doaj.org/toc/2399-3642Stüber et. al. show that receptor tyrosine kinase signaling can be neutralized through intermolecular, biparatopic bipDARPin crosslinking that locks down the bipDARPin-HER2 complexes. This affects the spatiotemporal organization and dynamics of HER2 in the plasma membrane.Jakob C. StüberChristian P. RichterJunel Sotolongo BellónMartin SchwillIwo KönigBenjamin SchulerJacob PiehlerAndreas PlückthunNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jakob C. Stüber Christian P. Richter Junel Sotolongo Bellón Martin Schwill Iwo König Benjamin Schuler Jacob Piehler Andreas Plückthun Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization
description	Stüber et. al. show that receptor tyrosine kinase signaling can be neutralized through intermolecular, biparatopic bipDARPin crosslinking that locks down the bipDARPin-HER2 complexes. This affects the spatiotemporal organization and dynamics of HER2 in the plasma membrane.
format	article
author	Jakob C. Stüber Christian P. Richter Junel Sotolongo Bellón Martin Schwill Iwo König Benjamin Schuler Jacob Piehler Andreas Plückthun
author_facet	Jakob C. Stüber Christian P. Richter Junel Sotolongo Bellón Martin Schwill Iwo König Benjamin Schuler Jacob Piehler Andreas Plückthun
author_sort	Jakob C. Stüber
title	Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization
title_short	Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization
title_full	Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization
title_fullStr	Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization
title_full_unstemmed	Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization
title_sort	apoptosis-inducing anti-her2 agents operate through oligomerization-induced receptor immobilization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/47e73f2b585647239c63400329c551bf
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Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization

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