PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development

PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development

The adrenal cortex undergoes functional zonation to generate an outer zona glomerulosa (ZG) and inner zona fasciculata (ZF), but how this is regulated at a molecular level is unclear. Here, the authors show that ZG differentiation is stimulated by WNT signalling and that PKA blocks WNT signalling to...

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Auteurs principaux: Coralie Drelon, Annabel Berthon, Isabelle Sahut-Barnola, Mickaël Mathieu, Typhanie Dumontet, Stéphanie Rodriguez, Marie Batisse-Lignier, Houda Tabbal, Igor Tauveron, Anne-Marie Lefrançois-Martinez, Jean-Christophe Pointud, Celso E. Gomez-Sanchez, Seppo Vainio, Jingdong Shan, Sonia Sacco, Andreas Schedl, Constantine A. Stratakis, Antoine Martinez, Pierre Val
Format: article
Langue:EN
Publié: Nature Portfolio 2016
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Science
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Accès en ligne:https://doaj.org/article/47e9d947aff442c7b85b4848141ee1ea
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Internet

https://doaj.org/article/47e9d947aff442c7b85b4848141ee1ea

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