PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development
The adrenal cortex undergoes functional zonation to generate an outer zona glomerulosa (ZG) and inner zona fasciculata (ZF), but how this is regulated at a molecular level is unclear. Here, the authors show that ZG differentiation is stimulated by WNT signalling and that PKA blocks WNT signalling to...
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Nature Portfolio
2016
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oai:doaj.org-article:47e9d947aff442c7b85b4848141ee1ea2021-12-02T17:32:39ZPKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development10.1038/ncomms127512041-1723https://doaj.org/article/47e9d947aff442c7b85b4848141ee1ea2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12751https://doaj.org/toc/2041-1723The adrenal cortex undergoes functional zonation to generate an outer zona glomerulosa (ZG) and inner zona fasciculata (ZF), but how this is regulated at a molecular level is unclear. Here, the authors show that ZG differentiation is stimulated by WNT signalling and that PKA blocks WNT signalling to allow ZF differentiation and also prevents WNT-induced cancer development.Coralie DrelonAnnabel BerthonIsabelle Sahut-BarnolaMickaël MathieuTyphanie DumontetStéphanie RodriguezMarie Batisse-LignierHouda TabbalIgor TauveronAnne-Marie Lefrançois-MartinezJean-Christophe PointudCelso E. Gomez-SanchezSeppo VainioJingdong ShanSonia SaccoAndreas SchedlConstantine A. StratakisAntoine MartinezPierre ValNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016) |
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Science Q Coralie Drelon Annabel Berthon Isabelle Sahut-Barnola Mickaël Mathieu Typhanie Dumontet Stéphanie Rodriguez Marie Batisse-Lignier Houda Tabbal Igor Tauveron Anne-Marie Lefrançois-Martinez Jean-Christophe Pointud Celso E. Gomez-Sanchez Seppo Vainio Jingdong Shan Sonia Sacco Andreas Schedl Constantine A. Stratakis Antoine Martinez Pierre Val PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development |
description |
The adrenal cortex undergoes functional zonation to generate an outer zona glomerulosa (ZG) and inner zona fasciculata (ZF), but how this is regulated at a molecular level is unclear. Here, the authors show that ZG differentiation is stimulated by WNT signalling and that PKA blocks WNT signalling to allow ZF differentiation and also prevents WNT-induced cancer development. |
format |
article |
author |
Coralie Drelon Annabel Berthon Isabelle Sahut-Barnola Mickaël Mathieu Typhanie Dumontet Stéphanie Rodriguez Marie Batisse-Lignier Houda Tabbal Igor Tauveron Anne-Marie Lefrançois-Martinez Jean-Christophe Pointud Celso E. Gomez-Sanchez Seppo Vainio Jingdong Shan Sonia Sacco Andreas Schedl Constantine A. Stratakis Antoine Martinez Pierre Val |
author_facet |
Coralie Drelon Annabel Berthon Isabelle Sahut-Barnola Mickaël Mathieu Typhanie Dumontet Stéphanie Rodriguez Marie Batisse-Lignier Houda Tabbal Igor Tauveron Anne-Marie Lefrançois-Martinez Jean-Christophe Pointud Celso E. Gomez-Sanchez Seppo Vainio Jingdong Shan Sonia Sacco Andreas Schedl Constantine A. Stratakis Antoine Martinez Pierre Val |
author_sort |
Coralie Drelon |
title |
PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development |
title_short |
PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development |
title_full |
PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development |
title_fullStr |
PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development |
title_full_unstemmed |
PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development |
title_sort |
pka inhibits wnt signalling in adrenal cortex zonation and prevents malignant tumour development |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/47e9d947aff442c7b85b4848141ee1ea |
work_keys_str_mv |
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