PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development

The adrenal cortex undergoes functional zonation to generate an outer zona glomerulosa (ZG) and inner zona fasciculata (ZF), but how this is regulated at a molecular level is unclear. Here, the authors show that ZG differentiation is stimulated by WNT signalling and that PKA blocks WNT signalling to...

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Autores principales: Coralie Drelon, Annabel Berthon, Isabelle Sahut-Barnola, Mickaël Mathieu, Typhanie Dumontet, Stéphanie Rodriguez, Marie Batisse-Lignier, Houda Tabbal, Igor Tauveron, Anne-Marie Lefrançois-Martinez, Jean-Christophe Pointud, Celso E. Gomez-Sanchez, Seppo Vainio, Jingdong Shan, Sonia Sacco, Andreas Schedl, Constantine A. Stratakis, Antoine Martinez, Pierre Val
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Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/47e9d947aff442c7b85b4848141ee1ea
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spelling oai:doaj.org-article:47e9d947aff442c7b85b4848141ee1ea2021-12-02T17:32:39ZPKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development10.1038/ncomms127512041-1723https://doaj.org/article/47e9d947aff442c7b85b4848141ee1ea2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12751https://doaj.org/toc/2041-1723The adrenal cortex undergoes functional zonation to generate an outer zona glomerulosa (ZG) and inner zona fasciculata (ZF), but how this is regulated at a molecular level is unclear. Here, the authors show that ZG differentiation is stimulated by WNT signalling and that PKA blocks WNT signalling to allow ZF differentiation and also prevents WNT-induced cancer development.Coralie DrelonAnnabel BerthonIsabelle Sahut-BarnolaMickaël MathieuTyphanie DumontetStéphanie RodriguezMarie Batisse-LignierHouda TabbalIgor TauveronAnne-Marie Lefrançois-MartinezJean-Christophe PointudCelso E. Gomez-SanchezSeppo VainioJingdong ShanSonia SaccoAndreas SchedlConstantine A. StratakisAntoine MartinezPierre ValNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Coralie Drelon
Annabel Berthon
Isabelle Sahut-Barnola
Mickaël Mathieu
Typhanie Dumontet
Stéphanie Rodriguez
Marie Batisse-Lignier
Houda Tabbal
Igor Tauveron
Anne-Marie Lefrançois-Martinez
Jean-Christophe Pointud
Celso E. Gomez-Sanchez
Seppo Vainio
Jingdong Shan
Sonia Sacco
Andreas Schedl
Constantine A. Stratakis
Antoine Martinez
Pierre Val
PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development
description The adrenal cortex undergoes functional zonation to generate an outer zona glomerulosa (ZG) and inner zona fasciculata (ZF), but how this is regulated at a molecular level is unclear. Here, the authors show that ZG differentiation is stimulated by WNT signalling and that PKA blocks WNT signalling to allow ZF differentiation and also prevents WNT-induced cancer development.
format article
author Coralie Drelon
Annabel Berthon
Isabelle Sahut-Barnola
Mickaël Mathieu
Typhanie Dumontet
Stéphanie Rodriguez
Marie Batisse-Lignier
Houda Tabbal
Igor Tauveron
Anne-Marie Lefrançois-Martinez
Jean-Christophe Pointud
Celso E. Gomez-Sanchez
Seppo Vainio
Jingdong Shan
Sonia Sacco
Andreas Schedl
Constantine A. Stratakis
Antoine Martinez
Pierre Val
author_facet Coralie Drelon
Annabel Berthon
Isabelle Sahut-Barnola
Mickaël Mathieu
Typhanie Dumontet
Stéphanie Rodriguez
Marie Batisse-Lignier
Houda Tabbal
Igor Tauveron
Anne-Marie Lefrançois-Martinez
Jean-Christophe Pointud
Celso E. Gomez-Sanchez
Seppo Vainio
Jingdong Shan
Sonia Sacco
Andreas Schedl
Constantine A. Stratakis
Antoine Martinez
Pierre Val
author_sort Coralie Drelon
title PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development
title_short PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development
title_full PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development
title_fullStr PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development
title_full_unstemmed PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development
title_sort pka inhibits wnt signalling in adrenal cortex zonation and prevents malignant tumour development
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/47e9d947aff442c7b85b4848141ee1ea
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