Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets

Increased availability of large-scale molecular profiling has enabled system-level monitoring of molecular effects of candidate therapeutics. Here, the authors take advantage of such data to show that the ability of a drug to reverse cancer-associated gene expression changes is indicative of itsin v...

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Autores principales:	Bin Chen, Li Ma, Hyojung Paik, Marina Sirota, Wei Wei, Mei-Sze Chua, Samuel So, Atul J. Butte
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/483c6f7f7ae94ba0a71118ed5cb81f74
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spelling	oai:doaj.org-article:483c6f7f7ae94ba0a71118ed5cb81f742021-12-02T17:06:15ZReversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets10.1038/ncomms160222041-1723https://doaj.org/article/483c6f7f7ae94ba0a71118ed5cb81f742017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16022https://doaj.org/toc/2041-1723Increased availability of large-scale molecular profiling has enabled system-level monitoring of molecular effects of candidate therapeutics. Here, the authors take advantage of such data to show that the ability of a drug to reverse cancer-associated gene expression changes is indicative of itsin vitroanti-proliferative efficacy, allowing them to identify novel compounds against liver cancer.Bin ChenLi MaHyojung PaikMarina SirotaWei WeiMei-Sze ChuaSamuel SoAtul J. ButteNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bin Chen Li Ma Hyojung Paik Marina Sirota Wei Wei Mei-Sze Chua Samuel So Atul J. Butte Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets
description	Increased availability of large-scale molecular profiling has enabled system-level monitoring of molecular effects of candidate therapeutics. Here, the authors take advantage of such data to show that the ability of a drug to reverse cancer-associated gene expression changes is indicative of itsin vitroanti-proliferative efficacy, allowing them to identify novel compounds against liver cancer.
format	article
author	Bin Chen Li Ma Hyojung Paik Marina Sirota Wei Wei Mei-Sze Chua Samuel So Atul J. Butte
author_facet	Bin Chen Li Ma Hyojung Paik Marina Sirota Wei Wei Mei-Sze Chua Samuel So Atul J. Butte
author_sort	Bin Chen
title	Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets
title_short	Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets
title_full	Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets
title_fullStr	Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets
title_full_unstemmed	Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets
title_sort	reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/483c6f7f7ae94ba0a71118ed5cb81f74
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Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets

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