Heterozygous and homozygous JAK2(V617F) states modeled by induced pluripotent stem cells from myeloproliferative neoplasm patients.

Heterozygous and homozygous JAK2(V617F) states modeled by induced pluripotent stem cells from myeloproliferative neoplasm patients.

JAK2(V617F) is the predominant mutation in myeloproliferative neoplasms (MPN). Modeling MPN in a human context might be helpful for the screening of molecules targeting JAK2 and its intracellular signaling. We describe here the derivation of induced pluripotent stem (iPS) cell lines from 2 polycythe...

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Auteurs principaux: Joseph Saliba, Sofiane Hamidi, Gaëlle Lenglet, Thierry Langlois, Jingkui Yin, Xénia Cabagnols, Lise Secardin, Céline Legrand, Anne Galy, Paule Opolon, Baya Benyahia, Eric Solary, Olivier A Bernard, Longyun Chen, Najet Debili, Hana Raslova, Françoise Norol, William Vainchenker, Isabelle Plo, Antonio Di Stefano
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2013
Sujets:
Medicine
R
Science
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Accès en ligne:https://doaj.org/article/485b12392cbc4958a40738009192500c
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https://doaj.org/article/485b12392cbc4958a40738009192500c

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