Activation of the NLRP3 inflammasome by IAV virulence protein PB1-F2 contributes to severe pathophysiology and disease.

The ability for a host to recognize infection is critical for virus clearance and often begins with induction of inflammation. The PB1-F2 of pathogenic influenza A viruses (IAV) contributes to the pathophysiology of infection, although the mechanism for this is unclear. The NLRP3-inflammasome has be...

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Autores principales: Julie L McAuley, Michelle D Tate, Charley J MacKenzie-Kludas, Anita Pinar, Weiguang Zeng, Andrea Stutz, Eicke Latz, Lorena E Brown, Ashley Mansell
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/487231b4cf484a60809c34176b8b5705
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