An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development

An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development

Argonaute 2 (AGO2) binds RAS and is required for cellular transformation. Here, the authors establish a KRAS-driven mouse model of pancreatic cancer with conditional loss of AGO2 and show that the early phase of neoplastic lesion initiation is dependent on EGFR/RAS but not AGO2, while AGO2 is requir...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Sunita Shankar, Jean Ching-Yi Tien, Ronald F. Siebenaler, Seema Chugh, Vijaya L. Dommeti, Sylvia Zelenka-Wang, Xiao-Ming Wang, Ingrid J. Apel, Jessica Waninger, Sanjana Eyunni, Alice Xu, Malay Mody, Andrew Goodrum, Yuping Zhang, John J. Tesmer, Rahul Mannan, Xuhong Cao, Pankaj Vats, Sethuramasundaram Pitchiaya, Stephanie J. Ellison, Jiaqi Shi, Chandan Kumar-Sinha, Howard C. Crawford, Arul M. Chinnaiyan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/4879439f815846169a9d5e62cae6d7c2
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Internet

https://doaj.org/article/4879439f815846169a9d5e62cae6d7c2

Ejemplares similares