An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development

An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development

Argonaute 2 (AGO2) binds RAS and is required for cellular transformation. Here, the authors establish a KRAS-driven mouse model of pancreatic cancer with conditional loss of AGO2 and show that the early phase of neoplastic lesion initiation is dependent on EGFR/RAS but not AGO2, while AGO2 is requir...

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Autores principales: Sunita Shankar, Jean Ching-Yi Tien, Ronald F. Siebenaler, Seema Chugh, Vijaya L. Dommeti, Sylvia Zelenka-Wang, Xiao-Ming Wang, Ingrid J. Apel, Jessica Waninger, Sanjana Eyunni, Alice Xu, Malay Mody, Andrew Goodrum, Yuping Zhang, John J. Tesmer, Rahul Mannan, Xuhong Cao, Pankaj Vats, Sethuramasundaram Pitchiaya, Stephanie J. Ellison, Jiaqi Shi, Chandan Kumar-Sinha, Howard C. Crawford, Arul M. Chinnaiyan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/4879439f815846169a9d5e62cae6d7c2
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spelling oai:doaj.org-article:4879439f815846169a9d5e62cae6d7c22021-12-02T17:51:19ZAn essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development10.1038/s41467-020-16309-22041-1723https://doaj.org/article/4879439f815846169a9d5e62cae6d7c22020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16309-2https://doaj.org/toc/2041-1723Argonaute 2 (AGO2) binds RAS and is required for cellular transformation. Here, the authors establish a KRAS-driven mouse model of pancreatic cancer with conditional loss of AGO2 and show that the early phase of neoplastic lesion initiation is dependent on EGFR/RAS but not AGO2, while AGO2 is required for pancreatic ductal adenocarcinoma progression and metastasis.Sunita ShankarJean Ching-Yi TienRonald F. SiebenalerSeema ChughVijaya L. DommetiSylvia Zelenka-WangXiao-Ming WangIngrid J. ApelJessica WaningerSanjana EyunniAlice XuMalay ModyAndrew GoodrumYuping ZhangJohn J. TesmerRahul MannanXuhong CaoPankaj VatsSethuramasundaram PitchiayaStephanie J. EllisonJiaqi ShiChandan Kumar-SinhaHoward C. CrawfordArul M. ChinnaiyanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sunita Shankar
Jean Ching-Yi Tien
Ronald F. Siebenaler
Seema Chugh
Vijaya L. Dommeti
Sylvia Zelenka-Wang
Xiao-Ming Wang
Ingrid J. Apel
Jessica Waninger
Sanjana Eyunni
Alice Xu
Malay Mody
Andrew Goodrum
Yuping Zhang
John J. Tesmer
Rahul Mannan
Xuhong Cao
Pankaj Vats
Sethuramasundaram Pitchiaya
Stephanie J. Ellison
Jiaqi Shi
Chandan Kumar-Sinha
Howard C. Crawford
Arul M. Chinnaiyan
An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development
description Argonaute 2 (AGO2) binds RAS and is required for cellular transformation. Here, the authors establish a KRAS-driven mouse model of pancreatic cancer with conditional loss of AGO2 and show that the early phase of neoplastic lesion initiation is dependent on EGFR/RAS but not AGO2, while AGO2 is required for pancreatic ductal adenocarcinoma progression and metastasis.
format article
author Sunita Shankar
Jean Ching-Yi Tien
Ronald F. Siebenaler
Seema Chugh
Vijaya L. Dommeti
Sylvia Zelenka-Wang
Xiao-Ming Wang
Ingrid J. Apel
Jessica Waninger
Sanjana Eyunni
Alice Xu
Malay Mody
Andrew Goodrum
Yuping Zhang
John J. Tesmer
Rahul Mannan
Xuhong Cao
Pankaj Vats
Sethuramasundaram Pitchiaya
Stephanie J. Ellison
Jiaqi Shi
Chandan Kumar-Sinha
Howard C. Crawford
Arul M. Chinnaiyan
author_facet Sunita Shankar
Jean Ching-Yi Tien
Ronald F. Siebenaler
Seema Chugh
Vijaya L. Dommeti
Sylvia Zelenka-Wang
Xiao-Ming Wang
Ingrid J. Apel
Jessica Waninger
Sanjana Eyunni
Alice Xu
Malay Mody
Andrew Goodrum
Yuping Zhang
John J. Tesmer
Rahul Mannan
Xuhong Cao
Pankaj Vats
Sethuramasundaram Pitchiaya
Stephanie J. Ellison
Jiaqi Shi
Chandan Kumar-Sinha
Howard C. Crawford
Arul M. Chinnaiyan
author_sort Sunita Shankar
title An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development
title_short An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development
title_full An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development
title_fullStr An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development
title_full_unstemmed An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development
title_sort essential role for argonaute 2 in egfr-kras signaling in pancreatic cancer development
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/4879439f815846169a9d5e62cae6d7c2
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