Anti-Aggregative Effect of the Antioxidant DJ-1 on the TPPP/p25-Derived Pathological Associations of Alpha-Synuclein

DJ-1, a multi-functional protein with antioxidant properties, protects dopaminergic neurons against Parkinson’s disease (PD). The oligomerization/assembly of alpha-synuclein (SYN), promoted by Tubulin Polymerization Promoting Protein (TPPP/p25), is fatal in the early stage of PD. The pathological as...

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Bibliographic Details
Main Authors: Judit Oláh, Attila Lehotzky, Tibor Szénási, Judit Ovádi
Format: article
Language:EN
Published: MDPI AG 2021
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Online Access:https://doaj.org/article/4895946aa1604e69b8204e8ea43c0786
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