Methylation and Expression of Mutant FUS in Motor Neurons Differentiated From Induced Pluripotent Stem Cells From ALS Patients

Methylation and Expression of Mutant FUS in Motor Neurons Differentiated From Induced Pluripotent Stem Cells From ALS Patients

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive disease leading to degeneration of motor neurons (MNs). Epigenetic modification of gene expression is increasingly recognized as potential disease mechanism. In the present study we generated motor neurons from induced pluripotent stem cel...

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Autores principales: T. Hartung, M. Rhein, N. Kalmbach, N. Thau-Habermann, M. Naujock, L. Müschen, H. Frieling, J. Sterneckert, A. Hermann, F. Wegner, S. Petri
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
amyotrophic lateral sclerosis
induced pluripotent stem cells derived motor neurons
FUS
methylation
DNA methyltransferases
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/489ab3ddbc6b46108b876a20cbaa97fb
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https://doaj.org/article/489ab3ddbc6b46108b876a20cbaa97fb

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