MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice.

Chronic low-grade inflammation in adipose tissue often accompanies obesity, leading to insulin resistance and increasing the risk for metabolic diseases. MAP3K8 (TPL2/COT) is an important signal transductor and activator of pro-inflammatory pathways that has been linked to obesity-induced adipose ti...

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Autores principales: Dov B Ballak, Peter van Essen, Janna A van Diepen, Henry Jansen, Anneke Hijmans, Tetsuya Matsuguchi, Helmut Sparrer, Cees J Tack, Mihai G Netea, Leo A B Joosten, Rinke Stienstra
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/48bc0581a7f04000bf62747d8c6338f4
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