Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis
Mutations in optineurin are associated with neurodegenerative diseases, including amyotrophic lateral sclerosis. Here, the authors report the structure of the ubiquitin binding domain of optineurin, which binds linear ubiquitin with homology to NEMO, and explore the function of this domain.
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Nature Portfolio
2016
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oai:doaj.org-article:48d2514f3f7d45fdab8f96492f0c4c452021-12-02T14:38:34ZLinear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis10.1038/ncomms125472041-1723https://doaj.org/article/48d2514f3f7d45fdab8f96492f0c4c452016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12547https://doaj.org/toc/2041-1723Mutations in optineurin are associated with neurodegenerative diseases, including amyotrophic lateral sclerosis. Here, the authors report the structure of the ubiquitin binding domain of optineurin, which binds linear ubiquitin with homology to NEMO, and explore the function of this domain.Seshiru NakazawaDaisuke OikawaRyohei IshiiTakashi AyakiHirotaka TakahashiHiroyuki TakedaRyuichiro IshitaniKiyoko KameiIzumi TakeyoshiHideshi KawakamiKazuhiro IwaiIzuho HatadaTatsuya SawasakiHidefumi ItoOsamu NurekiFuminori TokunagaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Seshiru Nakazawa Daisuke Oikawa Ryohei Ishii Takashi Ayaki Hirotaka Takahashi Hiroyuki Takeda Ryuichiro Ishitani Kiyoko Kamei Izumi Takeyoshi Hideshi Kawakami Kazuhiro Iwai Izuho Hatada Tatsuya Sawasaki Hidefumi Ito Osamu Nureki Fuminori Tokunaga Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis |
| description |
Mutations in optineurin are associated with neurodegenerative diseases, including amyotrophic lateral sclerosis. Here, the authors report the structure of the ubiquitin binding domain of optineurin, which binds linear ubiquitin with homology to NEMO, and explore the function of this domain. |
| format |
article |
| author |
Seshiru Nakazawa Daisuke Oikawa Ryohei Ishii Takashi Ayaki Hirotaka Takahashi Hiroyuki Takeda Ryuichiro Ishitani Kiyoko Kamei Izumi Takeyoshi Hideshi Kawakami Kazuhiro Iwai Izuho Hatada Tatsuya Sawasaki Hidefumi Ito Osamu Nureki Fuminori Tokunaga |
| author_facet |
Seshiru Nakazawa Daisuke Oikawa Ryohei Ishii Takashi Ayaki Hirotaka Takahashi Hiroyuki Takeda Ryuichiro Ishitani Kiyoko Kamei Izumi Takeyoshi Hideshi Kawakami Kazuhiro Iwai Izuho Hatada Tatsuya Sawasaki Hidefumi Ito Osamu Nureki Fuminori Tokunaga |
| author_sort |
Seshiru Nakazawa |
| title |
Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis |
| title_short |
Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis |
| title_full |
Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis |
| title_fullStr |
Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis |
| title_full_unstemmed |
Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis |
| title_sort |
linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/48d2514f3f7d45fdab8f96492f0c4c45 |
| work_keys_str_mv |
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| _version_ |
1718390947549544448 |