Structure of the respiratory MBS complex reveals iron-sulfur cluster catalyzed sulfane sulfur reduction in ancient life

The sulfur-reducing enzyme MBS and the hydrogen-gas evolving MBH are the evolutionary link between the ancestor Mrp antiporter and the mitochondrial respiratory complex I. Here, the authors characterise MBS from the hyperthermophilic archaeon Pyrococcus furiosus, solve its cryo-EM structure and disc...

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Autores principales:	Hongjun Yu, Dominik K. Haja, Gerrit J. Schut, Chang-Hao Wu, Xing Meng, Gongpu Zhao, Huilin Li, Michael W. W. Adams
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/48f8c0525140486e964bdeb38e02a289
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spelling	oai:doaj.org-article:48f8c0525140486e964bdeb38e02a2892021-12-02T14:16:55ZStructure of the respiratory MBS complex reveals iron-sulfur cluster catalyzed sulfane sulfur reduction in ancient life10.1038/s41467-020-19697-72041-1723https://doaj.org/article/48f8c0525140486e964bdeb38e02a2892020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19697-7https://doaj.org/toc/2041-1723The sulfur-reducing enzyme MBS and the hydrogen-gas evolving MBH are the evolutionary link between the ancestor Mrp antiporter and the mitochondrial respiratory complex I. Here, the authors characterise MBS from the hyperthermophilic archaeon Pyrococcus furiosus, solve its cryo-EM structure and discuss the structural evolution from Mrp to MBH and MBS and to the modern-day complex I.Hongjun YuDominik K. HajaGerrit J. SchutChang-Hao WuXing MengGongpu ZhaoHuilin LiMichael W. W. AdamsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hongjun Yu Dominik K. Haja Gerrit J. Schut Chang-Hao Wu Xing Meng Gongpu Zhao Huilin Li Michael W. W. Adams Structure of the respiratory MBS complex reveals iron-sulfur cluster catalyzed sulfane sulfur reduction in ancient life
description	The sulfur-reducing enzyme MBS and the hydrogen-gas evolving MBH are the evolutionary link between the ancestor Mrp antiporter and the mitochondrial respiratory complex I. Here, the authors characterise MBS from the hyperthermophilic archaeon Pyrococcus furiosus, solve its cryo-EM structure and discuss the structural evolution from Mrp to MBH and MBS and to the modern-day complex I.
format	article
author	Hongjun Yu Dominik K. Haja Gerrit J. Schut Chang-Hao Wu Xing Meng Gongpu Zhao Huilin Li Michael W. W. Adams
author_facet	Hongjun Yu Dominik K. Haja Gerrit J. Schut Chang-Hao Wu Xing Meng Gongpu Zhao Huilin Li Michael W. W. Adams
author_sort	Hongjun Yu
title	Structure of the respiratory MBS complex reveals iron-sulfur cluster catalyzed sulfane sulfur reduction in ancient life
title_short	Structure of the respiratory MBS complex reveals iron-sulfur cluster catalyzed sulfane sulfur reduction in ancient life
title_full	Structure of the respiratory MBS complex reveals iron-sulfur cluster catalyzed sulfane sulfur reduction in ancient life
title_fullStr	Structure of the respiratory MBS complex reveals iron-sulfur cluster catalyzed sulfane sulfur reduction in ancient life
title_full_unstemmed	Structure of the respiratory MBS complex reveals iron-sulfur cluster catalyzed sulfane sulfur reduction in ancient life
title_sort	structure of the respiratory mbs complex reveals iron-sulfur cluster catalyzed sulfane sulfur reduction in ancient life
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/48f8c0525140486e964bdeb38e02a289
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Structure of the respiratory MBS complex reveals iron-sulfur cluster catalyzed sulfane sulfur reduction in ancient life

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