The PAX3-FOXO1 oncogene alters exosome miRNA content and leads to paracrine effects mediated by exosomal miR-486
Abstract Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. The alveolar subtype (ARMS) is clinically more aggressive, and characterized by an oncogenic fusion protein PAX3-FOXO1 that drives oncogenic cellular properties. Exosomes are small, secreted vesicles that affect para...
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Autores principales: | , , , , , , , , |
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Formato: | article |
Lenguaje: | EN |
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Nature Portfolio
2019
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Acceso en línea: | https://doaj.org/article/48ff41dea4bf4d4aae9196741925086f |
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