Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations

Yang et al. examine whether genetic ancestry is associated with genetic variation in fatty acid desaturases and plasma phospholipid levels of long chain polyunsaturated fatty acids (LC-PUFAs) in Hispanic Americans. They find strong associations between Amerind genetic ancestry and LC-PUFA levels; an...

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Autores principales:	Chaojie Yang, Brian Hallmark, Jin Choul Chai, Timothy D. O’Connor, Lindsay M. Reynolds, Alexis C. Wood, Michael Seeds, Yii-Der Ida Chen, Lyn M. Steffen, Michael Y. Tsai, Robert C. Kaplan, Martha L. Daviglus, Lawrence J. Mandarino, Amanda M. Fretts, Rozenn N. Lemaitre, Dawn K. Coletta, Sarah A. Blomquist, Laurel M. Johnstone, Chandra Tontsch, Qibin Qi, Ingo Ruczinski, Stephen S. Rich, Rasika A. Mathias, Floyd H. Chilton, Ani Manichaikul
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/490453d6665243aba801e3d3ea7f205f
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spelling	oai:doaj.org-article:490453d6665243aba801e3d3ea7f205f2021-12-02T16:31:01ZImpact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations10.1038/s42003-021-02431-42399-3642https://doaj.org/article/490453d6665243aba801e3d3ea7f205f2021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02431-4https://doaj.org/toc/2399-3642Yang et al. examine whether genetic ancestry is associated with genetic variation in fatty acid desaturases and plasma phospholipid levels of long chain polyunsaturated fatty acids (LC-PUFAs) in Hispanic Americans. They find strong associations between Amerind genetic ancestry and LC-PUFA levels; and report that the well-known FADS rs174537 variant was associated with several metabolic, inflammatory and anthropomorphic traits including circulating triglycerides.Chaojie YangBrian HallmarkJin Choul ChaiTimothy D. O’ConnorLindsay M. ReynoldsAlexis C. WoodMichael SeedsYii-Der Ida ChenLyn M. SteffenMichael Y. TsaiRobert C. KaplanMartha L. DaviglusLawrence J. MandarinoAmanda M. FrettsRozenn N. LemaitreDawn K. ColettaSarah A. BlomquistLaurel M. JohnstoneChandra TontschQibin QiIngo RuczinskiStephen S. RichRasika A. MathiasFloyd H. ChiltonAni ManichaikulNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Chaojie Yang Brian Hallmark Jin Choul Chai Timothy D. O’Connor Lindsay M. Reynolds Alexis C. Wood Michael Seeds Yii-Der Ida Chen Lyn M. Steffen Michael Y. Tsai Robert C. Kaplan Martha L. Daviglus Lawrence J. Mandarino Amanda M. Fretts Rozenn N. Lemaitre Dawn K. Coletta Sarah A. Blomquist Laurel M. Johnstone Chandra Tontsch Qibin Qi Ingo Ruczinski Stephen S. Rich Rasika A. Mathias Floyd H. Chilton Ani Manichaikul Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations
description	Yang et al. examine whether genetic ancestry is associated with genetic variation in fatty acid desaturases and plasma phospholipid levels of long chain polyunsaturated fatty acids (LC-PUFAs) in Hispanic Americans. They find strong associations between Amerind genetic ancestry and LC-PUFA levels; and report that the well-known FADS rs174537 variant was associated with several metabolic, inflammatory and anthropomorphic traits including circulating triglycerides.
format	article
author	Chaojie Yang Brian Hallmark Jin Choul Chai Timothy D. O’Connor Lindsay M. Reynolds Alexis C. Wood Michael Seeds Yii-Der Ida Chen Lyn M. Steffen Michael Y. Tsai Robert C. Kaplan Martha L. Daviglus Lawrence J. Mandarino Amanda M. Fretts Rozenn N. Lemaitre Dawn K. Coletta Sarah A. Blomquist Laurel M. Johnstone Chandra Tontsch Qibin Qi Ingo Ruczinski Stephen S. Rich Rasika A. Mathias Floyd H. Chilton Ani Manichaikul
author_facet	Chaojie Yang Brian Hallmark Jin Choul Chai Timothy D. O’Connor Lindsay M. Reynolds Alexis C. Wood Michael Seeds Yii-Der Ida Chen Lyn M. Steffen Michael Y. Tsai Robert C. Kaplan Martha L. Daviglus Lawrence J. Mandarino Amanda M. Fretts Rozenn N. Lemaitre Dawn K. Coletta Sarah A. Blomquist Laurel M. Johnstone Chandra Tontsch Qibin Qi Ingo Ruczinski Stephen S. Rich Rasika A. Mathias Floyd H. Chilton Ani Manichaikul
author_sort	Chaojie Yang
title	Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations
title_short	Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations
title_full	Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations
title_fullStr	Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations
title_full_unstemmed	Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations
title_sort	impact of amerind ancestry and fads genetic variation on omega-3 deficiency and cardiometabolic traits in hispanic populations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/490453d6665243aba801e3d3ea7f205f
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Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations

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