The methylome of the celiac intestinal epithelium harbours genotype-independent alterations in the HLA region

The methylome of the celiac intestinal epithelium harbours genotype-independent alterations in the HLA region

Abstract The Human Leucocyte Antigen (HLA) locus and other DNA sequence variants identified in Genome-Wide Association (GWA) studies explain around 50% of the heritability of celiac disease (CD). However, the pathogenesis of CD could be driven by other layers of genomic information independent from...

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Autores principales: Nora Fernandez-Jimenez, Koldo Garcia-Etxebarria, Leticia Plaza-Izurieta, Irati Romero-Garmendia, Amaia Jauregi-Miguel, Maria Legarda, Szilvia Ecsedi, Ainara Castellanos-Rubio, Vincent Cahais, Cyrille Cuenin, Davide Degli Esposti, Iñaki Irastorza, Hector Hernandez-Vargas, Zdenko Herceg, Jose Ramon Bilbao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/49108c83776145ee885324a210722b7d
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https://doaj.org/article/49108c83776145ee885324a210722b7d

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