JAK2-STAT Epigenetically Regulates Tolerized Genes in Monocytes in the First Encounter With Gram-Negative Bacterial Endotoxins in Sepsis

JAK2-STAT Epigenetically Regulates Tolerized Genes in Monocytes in the First Encounter With Gram-Negative Bacterial Endotoxins in Sepsis

Microbial challenges, such as widespread bacterial infection in sepsis, induce endotoxin tolerance, a state of hyporesponsiveness to subsequent infections. The participation of DNA methylation in this process is poorly known. In this study, we perform integrated analysis of DNA methylation and trans...

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Autores principales: Octavio Morante-Palacios, Clara Lorente-Sorolla, Laura Ciudad, Josep Calafell-Segura, Antonio Garcia-Gomez, Francesc Català-Moll, Adolfo Ruiz-Sanmartín, Mónica Martínez-Gallo, Ricard Ferrer, Juan Carlos Ruiz-Rodriguez, Damiana Álvarez-Errico, Esteban Ballestar
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
monocytes
endotoxin tolerance
sepsis
DNA methylation
tolerized genes
STATs
Immunologic diseases. Allergy
RC581-607
Acceso en línea:https://doaj.org/article/49184cea2fcd4e56b292273927f9285f
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https://doaj.org/article/49184cea2fcd4e56b292273927f9285f

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