NLRP11 attenuates Toll-like receptor signalling by targeting TRAF6 for degradation via the ubiquitin ligase RNF19A

NLRP11 is a primate-specific NOD-like receptor with unclear function. Here the authors show NLRP11 is an inhibitory protein that targets TRAF6 for K48 ubiquitination-mediated proteasomal degradation to limit inflammatory responses.

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Auteurs principaux:	Chenglei Wu, Zexiong Su, Meng Lin, Jiayu Ou, Wei Zhao, Jun Cui, Rong-Fu Wang
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/49195c6d131f44acbb15bcafd45c38b3
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id	oai:doaj.org-article:49195c6d131f44acbb15bcafd45c38b3
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spelling	oai:doaj.org-article:49195c6d131f44acbb15bcafd45c38b32021-12-02T15:37:05ZNLRP11 attenuates Toll-like receptor signalling by targeting TRAF6 for degradation via the ubiquitin ligase RNF19A10.1038/s41467-017-02073-32041-1723https://doaj.org/article/49195c6d131f44acbb15bcafd45c38b32017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02073-3https://doaj.org/toc/2041-1723NLRP11 is a primate-specific NOD-like receptor with unclear function. Here the authors show NLRP11 is an inhibitory protein that targets TRAF6 for K48 ubiquitination-mediated proteasomal degradation to limit inflammatory responses.Chenglei WuZexiong SuMeng LinJiayu OuWei ZhaoJun CuiRong-Fu WangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chenglei Wu Zexiong Su Meng Lin Jiayu Ou Wei Zhao Jun Cui Rong-Fu Wang NLRP11 attenuates Toll-like receptor signalling by targeting TRAF6 for degradation via the ubiquitin ligase RNF19A
description	NLRP11 is a primate-specific NOD-like receptor with unclear function. Here the authors show NLRP11 is an inhibitory protein that targets TRAF6 for K48 ubiquitination-mediated proteasomal degradation to limit inflammatory responses.
format	article
author	Chenglei Wu Zexiong Su Meng Lin Jiayu Ou Wei Zhao Jun Cui Rong-Fu Wang
author_facet	Chenglei Wu Zexiong Su Meng Lin Jiayu Ou Wei Zhao Jun Cui Rong-Fu Wang
author_sort	Chenglei Wu
title	NLRP11 attenuates Toll-like receptor signalling by targeting TRAF6 for degradation via the ubiquitin ligase RNF19A
title_short	NLRP11 attenuates Toll-like receptor signalling by targeting TRAF6 for degradation via the ubiquitin ligase RNF19A
title_full	NLRP11 attenuates Toll-like receptor signalling by targeting TRAF6 for degradation via the ubiquitin ligase RNF19A
title_fullStr	NLRP11 attenuates Toll-like receptor signalling by targeting TRAF6 for degradation via the ubiquitin ligase RNF19A
title_full_unstemmed	NLRP11 attenuates Toll-like receptor signalling by targeting TRAF6 for degradation via the ubiquitin ligase RNF19A
title_sort	nlrp11 attenuates toll-like receptor signalling by targeting traf6 for degradation via the ubiquitin ligase rnf19a
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/49195c6d131f44acbb15bcafd45c38b3
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NLRP11 attenuates Toll-like receptor signalling by targeting TRAF6 for degradation via the ubiquitin ligase RNF19A

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