Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease

Abnormal accumulations of toxic proteins are often found in degenerating neurons. Here, Aron and colleagues show that non-enzymatic function of deubiquitinase Usp12 can mitigate neuronal cell death caused by mutant Huntingtin by inducing neuronal autophagic function.

Guardado en:
Detalles Bibliográficos
Autores principales: Rebecca Aron, Pasquale Pellegrini, Edward W. Green, Daniel C. Maddison, Kwadwo Opoku-Nsiah, Anna Osorio Oliveira, Jinny S. Wong, Aaron C. Daub, Flaviano Giorgini, Paul Muchowski, Steven Finkbeiner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Q
Acceso en línea:https://doaj.org/article/491c3dd275b146cfb2bdfa21d0bb5d6e
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!