Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease

Abnormal accumulations of toxic proteins are often found in degenerating neurons. Here, Aron and colleagues show that non-enzymatic function of deubiquitinase Usp12 can mitigate neuronal cell death caused by mutant Huntingtin by inducing neuronal autophagic function.

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Autores principales:	Rebecca Aron, Pasquale Pellegrini, Edward W. Green, Daniel C. Maddison, Kwadwo Opoku-Nsiah, Anna Osorio Oliveira, Jinny S. Wong, Aaron C. Daub, Flaviano Giorgini, Paul Muchowski, Steven Finkbeiner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/491c3dd275b146cfb2bdfa21d0bb5d6e
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spelling	oai:doaj.org-article:491c3dd275b146cfb2bdfa21d0bb5d6e2021-12-02T17:31:13ZDeubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease10.1038/s41467-018-05653-z2041-1723https://doaj.org/article/491c3dd275b146cfb2bdfa21d0bb5d6e2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05653-zhttps://doaj.org/toc/2041-1723Abnormal accumulations of toxic proteins are often found in degenerating neurons. Here, Aron and colleagues show that non-enzymatic function of deubiquitinase Usp12 can mitigate neuronal cell death caused by mutant Huntingtin by inducing neuronal autophagic function.Rebecca AronPasquale PellegriniEdward W. GreenDaniel C. MaddisonKwadwo Opoku-NsiahAnna Osorio OliveiraJinny S. WongAaron C. DaubFlaviano GiorginiPaul MuchowskiSteven FinkbeinerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rebecca Aron Pasquale Pellegrini Edward W. Green Daniel C. Maddison Kwadwo Opoku-Nsiah Anna Osorio Oliveira Jinny S. Wong Aaron C. Daub Flaviano Giorgini Paul Muchowski Steven Finkbeiner Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease
description	Abnormal accumulations of toxic proteins are often found in degenerating neurons. Here, Aron and colleagues show that non-enzymatic function of deubiquitinase Usp12 can mitigate neuronal cell death caused by mutant Huntingtin by inducing neuronal autophagic function.
format	article
author	Rebecca Aron Pasquale Pellegrini Edward W. Green Daniel C. Maddison Kwadwo Opoku-Nsiah Anna Osorio Oliveira Jinny S. Wong Aaron C. Daub Flaviano Giorgini Paul Muchowski Steven Finkbeiner
author_facet	Rebecca Aron Pasquale Pellegrini Edward W. Green Daniel C. Maddison Kwadwo Opoku-Nsiah Anna Osorio Oliveira Jinny S. Wong Aaron C. Daub Flaviano Giorgini Paul Muchowski Steven Finkbeiner
author_sort	Rebecca Aron
title	Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease
title_short	Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease
title_full	Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease
title_fullStr	Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease
title_full_unstemmed	Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease
title_sort	deubiquitinase usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of huntington’s disease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/491c3dd275b146cfb2bdfa21d0bb5d6e
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Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease

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