Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease

Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease

Abnormal accumulations of toxic proteins are often found in degenerating neurons. Here, Aron and colleagues show that non-enzymatic function of deubiquitinase Usp12 can mitigate neuronal cell death caused by mutant Huntingtin by inducing neuronal autophagic function.

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Detalles Bibliográficos
Autores principales: Rebecca Aron, Pasquale Pellegrini, Edward W. Green, Daniel C. Maddison, Kwadwo Opoku-Nsiah, Anna Osorio Oliveira, Jinny S. Wong, Aaron C. Daub, Flaviano Giorgini, Paul Muchowski, Steven Finkbeiner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/491c3dd275b146cfb2bdfa21d0bb5d6e
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