Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41

Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41

A common susceptibility haplotype for renal cell carcinoma is located on chromosome 12p12.1. Here, the authors show that the variant rs7132434 alters binding of the AP-1 transcription factor, which increases the expression of BHLHE41in renal cells.

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Bibliographic Details
Main Authors: Pierre Bigot, Leandro M. Colli, Mitchell J. Machiela, Lea Jessop, Timothy A. Myers, Julie Carrouget, Sarah Wagner, David Roberson, Caroline Eymerit, Daniel Henrion, Stephen J. Chanock
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
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Online Access:https://doaj.org/article/491e789fb6bb4a9cb1b61e406a372877
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https://doaj.org/article/491e789fb6bb4a9cb1b61e406a372877

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