Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41

A common susceptibility haplotype for renal cell carcinoma is located on chromosome 12p12.1. Here, the authors show that the variant rs7132434 alters binding of the AP-1 transcription factor, which increases the expression of BHLHE41in renal cells.

Guardado en:

Detalles Bibliográficos
Autores principales:	Pierre Bigot, Leandro M. Colli, Mitchell J. Machiela, Lea Jessop, Timothy A. Myers, Julie Carrouget, Sarah Wagner, David Roberson, Caroline Eymerit, Daniel Henrion, Stephen J. Chanock
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/491e789fb6bb4a9cb1b61e406a372877
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:491e789fb6bb4a9cb1b61e406a372877
record_format	dspace
spelling	oai:doaj.org-article:491e789fb6bb4a9cb1b61e406a3728772021-12-02T15:33:48ZFunctional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE4110.1038/ncomms120982041-1723https://doaj.org/article/491e789fb6bb4a9cb1b61e406a3728772016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12098https://doaj.org/toc/2041-1723A common susceptibility haplotype for renal cell carcinoma is located on chromosome 12p12.1. Here, the authors show that the variant rs7132434 alters binding of the AP-1 transcription factor, which increases the expression of BHLHE41in renal cells.Pierre BigotLeandro M. ColliMitchell J. MachielaLea JessopTimothy A. MyersJulie CarrougetSarah WagnerDavid RobersonCaroline EymeritDaniel HenrionStephen J. ChanockNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pierre Bigot Leandro M. Colli Mitchell J. Machiela Lea Jessop Timothy A. Myers Julie Carrouget Sarah Wagner David Roberson Caroline Eymerit Daniel Henrion Stephen J. Chanock Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41
description	A common susceptibility haplotype for renal cell carcinoma is located on chromosome 12p12.1. Here, the authors show that the variant rs7132434 alters binding of the AP-1 transcription factor, which increases the expression of BHLHE41in renal cells.
format	article
author	Pierre Bigot Leandro M. Colli Mitchell J. Machiela Lea Jessop Timothy A. Myers Julie Carrouget Sarah Wagner David Roberson Caroline Eymerit Daniel Henrion Stephen J. Chanock
author_facet	Pierre Bigot Leandro M. Colli Mitchell J. Machiela Lea Jessop Timothy A. Myers Julie Carrouget Sarah Wagner David Roberson Caroline Eymerit Daniel Henrion Stephen J. Chanock
author_sort	Pierre Bigot
title	Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41
title_short	Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41
title_full	Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41
title_fullStr	Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41
title_full_unstemmed	Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41
title_sort	functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates bhlhe41
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/491e789fb6bb4a9cb1b61e406a372877
work_keys_str_mv	AT pierrebigot functionalcharacterizationofthe12p121renalcancersusceptibilitylocusimplicatesbhlhe41 AT leandromcolli functionalcharacterizationofthe12p121renalcancersusceptibilitylocusimplicatesbhlhe41 AT mitchelljmachiela functionalcharacterizationofthe12p121renalcancersusceptibilitylocusimplicatesbhlhe41 AT leajessop functionalcharacterizationofthe12p121renalcancersusceptibilitylocusimplicatesbhlhe41 AT timothyamyers functionalcharacterizationofthe12p121renalcancersusceptibilitylocusimplicatesbhlhe41 AT juliecarrouget functionalcharacterizationofthe12p121renalcancersusceptibilitylocusimplicatesbhlhe41 AT sarahwagner functionalcharacterizationofthe12p121renalcancersusceptibilitylocusimplicatesbhlhe41 AT davidroberson functionalcharacterizationofthe12p121renalcancersusceptibilitylocusimplicatesbhlhe41 AT carolineeymerit functionalcharacterizationofthe12p121renalcancersusceptibilitylocusimplicatesbhlhe41 AT danielhenrion functionalcharacterizationofthe12p121renalcancersusceptibilitylocusimplicatesbhlhe41 AT stephenjchanock functionalcharacterizationofthe12p121renalcancersusceptibilitylocusimplicatesbhlhe41
_version_	1718387021396836352

Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41

Ejemplares similares