TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors

TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors

Interferons have been shown to mediate tumour rejection. Here, in a spontaneous mouse model of breast cancer, the authors show that this is disrupted owing to high levels of TGFβ produced in the tumour.

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Autores principales: Marion V. Guerin, Fabienne Regnier, Vincent Feuillet, Lene Vimeux, Julia M. Weiss, Georges Bismuth, Gregoire Altan-Bonnet, Thomas Guilbert, Maxime Thoreau, Veronica Finisguerra, Emmanuel Donnadieu, Alain Trautmann, Nadège Bercovici
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/4998cfedc6d240aeaec2f8249ea1a3ed
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spelling oai:doaj.org-article:4998cfedc6d240aeaec2f8249ea1a3ed2021-12-02T14:40:21ZTGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors10.1038/s41467-019-11998-w2041-1723https://doaj.org/article/4998cfedc6d240aeaec2f8249ea1a3ed2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11998-whttps://doaj.org/toc/2041-1723Interferons have been shown to mediate tumour rejection. Here, in a spontaneous mouse model of breast cancer, the authors show that this is disrupted owing to high levels of TGFβ produced in the tumour.Marion V. GuerinFabienne RegnierVincent FeuilletLene VimeuxJulia M. WeissGeorges BismuthGregoire Altan-BonnetThomas GuilbertMaxime ThoreauVeronica FinisguerraEmmanuel DonnadieuAlain TrautmannNadège BercoviciNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Marion V. Guerin
Fabienne Regnier
Vincent Feuillet
Lene Vimeux
Julia M. Weiss
Georges Bismuth
Gregoire Altan-Bonnet
Thomas Guilbert
Maxime Thoreau
Veronica Finisguerra
Emmanuel Donnadieu
Alain Trautmann
Nadège Bercovici
TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors
description Interferons have been shown to mediate tumour rejection. Here, in a spontaneous mouse model of breast cancer, the authors show that this is disrupted owing to high levels of TGFβ produced in the tumour.
format article
author Marion V. Guerin
Fabienne Regnier
Vincent Feuillet
Lene Vimeux
Julia M. Weiss
Georges Bismuth
Gregoire Altan-Bonnet
Thomas Guilbert
Maxime Thoreau
Veronica Finisguerra
Emmanuel Donnadieu
Alain Trautmann
Nadège Bercovici
author_facet Marion V. Guerin
Fabienne Regnier
Vincent Feuillet
Lene Vimeux
Julia M. Weiss
Georges Bismuth
Gregoire Altan-Bonnet
Thomas Guilbert
Maxime Thoreau
Veronica Finisguerra
Emmanuel Donnadieu
Alain Trautmann
Nadège Bercovici
author_sort Marion V. Guerin
title TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors
title_short TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors
title_full TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors
title_fullStr TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors
title_full_unstemmed TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors
title_sort tgfβ blocks ifnα/β release and tumor rejection in spontaneous mammary tumors
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/4998cfedc6d240aeaec2f8249ea1a3ed
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