IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation

IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation

IL-6 is an important cytokine in the tumour microenvironment, but its role in regulating autophagy in cancer cells is unclear. Here the authors show that IL-6 activates autophagy in colorectal cancer through the interaction between JAK2 and autophagy regulator, BECN1, which leads to chemotherapeutic...

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Bibliographic Details
Main Authors: Fuqing Hu, Da Song, Yumeng Yan, Changsheng Huang, Chentao Shen, Jingqin Lan, Yaqi Chen, Anyi Liu, Qi Wu, Li Sun, Feng Xu, Fayong Hu, Lisheng Chen, Xuelai Luo, Yongdong Feng, Shengyou Huang, Junbo Hu, Guihua Wang
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/49b6d3166a0d4dc385c9d90171668cf8
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https://doaj.org/article/49b6d3166a0d4dc385c9d90171668cf8

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