Central dogma rates and the trade-off between precision and economy in gene expression

The same protein abundance can be achieved by many combinations of transcription, translation and degradation rates. Here, the authors find that genes combining high transcription with low translation rate are rare due to a trade-off between the cost of transcription and expression noise.

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Detalles Bibliográficos
Autores principales:	Jean Hausser, Avi Mayo, Leeat Keren, Uri Alon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/49c76385217d4abdbed2391068e344b2
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spelling	oai:doaj.org-article:49c76385217d4abdbed2391068e344b22021-12-02T17:01:41ZCentral dogma rates and the trade-off between precision and economy in gene expression10.1038/s41467-018-07391-82041-1723https://doaj.org/article/49c76385217d4abdbed2391068e344b22019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07391-8https://doaj.org/toc/2041-1723The same protein abundance can be achieved by many combinations of transcription, translation and degradation rates. Here, the authors find that genes combining high transcription with low translation rate are rare due to a trade-off between the cost of transcription and expression noise.Jean HausserAvi MayoLeeat KerenUri AlonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jean Hausser Avi Mayo Leeat Keren Uri Alon Central dogma rates and the trade-off between precision and economy in gene expression
description	The same protein abundance can be achieved by many combinations of transcription, translation and degradation rates. Here, the authors find that genes combining high transcription with low translation rate are rare due to a trade-off between the cost of transcription and expression noise.
format	article
author	Jean Hausser Avi Mayo Leeat Keren Uri Alon
author_facet	Jean Hausser Avi Mayo Leeat Keren Uri Alon
author_sort	Jean Hausser
title	Central dogma rates and the trade-off between precision and economy in gene expression
title_short	Central dogma rates and the trade-off between precision and economy in gene expression
title_full	Central dogma rates and the trade-off between precision and economy in gene expression
title_fullStr	Central dogma rates and the trade-off between precision and economy in gene expression
title_full_unstemmed	Central dogma rates and the trade-off between precision and economy in gene expression
title_sort	central dogma rates and the trade-off between precision and economy in gene expression
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/49c76385217d4abdbed2391068e344b2
work_keys_str_mv	AT jeanhausser centraldogmaratesandthetradeoffbetweenprecisionandeconomyingeneexpression AT avimayo centraldogmaratesandthetradeoffbetweenprecisionandeconomyingeneexpression AT leeatkeren centraldogmaratesandthetradeoffbetweenprecisionandeconomyingeneexpression AT urialon centraldogmaratesandthetradeoffbetweenprecisionandeconomyingeneexpression
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Central dogma rates and the trade-off between precision and economy in gene expression

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