Molecular basis of AKAP79 regulation by calmodulin

The A-kinase anchoring protein AKAP79 is regulated by calmodulin (CaM). Here, the authors use crosslinking coupled to mass spectrometry to identify the CaM-binding site in AKAP79 and present the structure of CaM bound to an AKAP79 peptide. The structure shows that CaM adopts a highly compact conform...

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Auteurs principaux: Neha Patel, Florian Stengel, Ruedi Aebersold, Matthew G. Gold
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Accès en ligne:https://doaj.org/article/49cdec22e2cc46518168ece42a2d109f
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