Molecular basis of AKAP79 regulation by calmodulin

The A-kinase anchoring protein AKAP79 is regulated by calmodulin (CaM). Here, the authors use crosslinking coupled to mass spectrometry to identify the CaM-binding site in AKAP79 and present the structure of CaM bound to an AKAP79 peptide. The structure shows that CaM adopts a highly compact conform...

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Autores principales:	Neha Patel, Florian Stengel, Ruedi Aebersold, Matthew G. Gold
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/49cdec22e2cc46518168ece42a2d109f
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spelling	oai:doaj.org-article:49cdec22e2cc46518168ece42a2d109f2021-12-02T17:01:24ZMolecular basis of AKAP79 regulation by calmodulin10.1038/s41467-017-01715-w2041-1723https://doaj.org/article/49cdec22e2cc46518168ece42a2d109f2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01715-whttps://doaj.org/toc/2041-1723The A-kinase anchoring protein AKAP79 is regulated by calmodulin (CaM). Here, the authors use crosslinking coupled to mass spectrometry to identify the CaM-binding site in AKAP79 and present the structure of CaM bound to an AKAP79 peptide. The structure shows that CaM adopts a highly compact conformation to interact with a mixed α/310 helix in AKAP79.Neha PatelFlorian StengelRuedi AebersoldMatthew G. GoldNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Neha Patel Florian Stengel Ruedi Aebersold Matthew G. Gold Molecular basis of AKAP79 regulation by calmodulin
description	The A-kinase anchoring protein AKAP79 is regulated by calmodulin (CaM). Here, the authors use crosslinking coupled to mass spectrometry to identify the CaM-binding site in AKAP79 and present the structure of CaM bound to an AKAP79 peptide. The structure shows that CaM adopts a highly compact conformation to interact with a mixed α/310 helix in AKAP79.
format	article
author	Neha Patel Florian Stengel Ruedi Aebersold Matthew G. Gold
author_facet	Neha Patel Florian Stengel Ruedi Aebersold Matthew G. Gold
author_sort	Neha Patel
title	Molecular basis of AKAP79 regulation by calmodulin
title_short	Molecular basis of AKAP79 regulation by calmodulin
title_full	Molecular basis of AKAP79 regulation by calmodulin
title_fullStr	Molecular basis of AKAP79 regulation by calmodulin
title_full_unstemmed	Molecular basis of AKAP79 regulation by calmodulin
title_sort	molecular basis of akap79 regulation by calmodulin
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/49cdec22e2cc46518168ece42a2d109f
work_keys_str_mv	AT nehapatel molecularbasisofakap79regulationbycalmodulin AT florianstengel molecularbasisofakap79regulationbycalmodulin AT ruediaebersold molecularbasisofakap79regulationbycalmodulin AT matthewggold molecularbasisofakap79regulationbycalmodulin
_version_	1718382143591153664

Molecular basis of AKAP79 regulation by calmodulin

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