Molecular Preadaptation to Antimony Resistance in <named-content content-type="genus-species">Leishmania donovani</named-content> on the Indian Subcontinent

Molecular Preadaptation to Antimony Resistance in <named-content content-type="genus-species">Leishmania donovani</named-content> on the Indian Subcontinent

ABSTRACT Antimonials (Sb) were used for decades for chemotherapy of visceral leishmaniasis (VL). Now abandoned in the Indian subcontinent (ISC) because of Leishmania donovani resistance, this drug offers a unique model for understanding drug resistance dynamics. In a previous phylogenomic study, we...

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Bibliographic Details
Main Authors: F. Dumetz, B. Cuypers, H. Imamura, D. Zander, E. D’Haenens, I. Maes, M. A. Domagalska, J. Clos, J.-C. Dujardin, G. De Muylder
Format: article
Language:EN
Published: American Society for Microbiology 2018
Subjects:
Leishmania
antimonials
drug resistance mechanisms
genomics
metabolomics
Microbiology
QR1-502
Online Access:https://doaj.org/article/49d1e1a7b21a47fe86a8b1efe9962b80
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