A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis

The integral membrane protein Apq12 is an important nuclear envelope (NE)/endoplasmic reticulum (ER) modulator that cooperates with the nuclear pore complex (NPC) biogenesis factors Brl1 and Brr6. How Apq12 executes these functions is unknown. Here, we identified a short amphipathic α-helix (AαH) in...

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Autores principales: Wanlu Zhang, Azqa Khan, Jlenia Vitale, Annett Neuner, Kerstin Rink, Christian Lüchtenborg, Britta Brügger, Thomas H. Söllner, Elmar Schiebel
Formato: article
Lenguaje:EN
Publicado: The Royal Society 2021
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Acceso en línea:https://doaj.org/article/49f2b3970e5e42359e25debff6fe7f98
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