Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation

Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation

Allogeneic hematopoietic cell transplantation (allo-HCT) has led to the cure of HIV in one individual, but the underlying mechanisms are unclear. Here, the authors present a model of allo-HCT in SHIV-infected nonhuman primates and show that the SHIV reservoir persists in multiple tissues early after...

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Autores principales: Lucrezia Colonna, Christopher W. Peterson, John B. Schell, Judith M. Carlson, Victor Tkachev, Melanie Brown, Alison Yu, Sowmya Reddy, Willi M. Obenza, Veronica Nelson, Patricia S. Polacino, Heather Mack, Shiu-Lok Hu, Katie Zeleski, Michelle Hoffman, Joe Olvera, Scott N. Furlan, Hengqi Zheng, Agne Taraseviciute, Daniel J. Hunt, Kayla Betz, Jennifer F. Lane, Keith Vogel, Charlotte E. Hotchkiss, Cassie Moats, Audrey Baldessari, Robert D. Murnane, Christopher English, Cliff A. Astley, Solomon Wangari, Brian Agricola, Joel Ahrens, Naoto Iwayama, Andrew May, Laurence Stensland, Meei-Li W. Huang, Keith R. Jerome, Hans-Peter Kiem, Leslie S. Kean
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/4a76aae13cb3419a93e2049fc08cebbe
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spelling oai:doaj.org-article:4a76aae13cb3419a93e2049fc08cebbe2021-12-02T17:33:17ZEvidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation10.1038/s41467-018-06736-72041-1723https://doaj.org/article/4a76aae13cb3419a93e2049fc08cebbe2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06736-7https://doaj.org/toc/2041-1723Allogeneic hematopoietic cell transplantation (allo-HCT) has led to the cure of HIV in one individual, but the underlying mechanisms are unclear. Here, the authors present a model of allo-HCT in SHIV-infected nonhuman primates and show that the SHIV reservoir persists in multiple tissues early after transplantation.Lucrezia ColonnaChristopher W. PetersonJohn B. SchellJudith M. CarlsonVictor TkachevMelanie BrownAlison YuSowmya ReddyWilli M. ObenzaVeronica NelsonPatricia S. PolacinoHeather MackShiu-Lok HuKatie ZeleskiMichelle HoffmanJoe OlveraScott N. FurlanHengqi ZhengAgne TaraseviciuteDaniel J. HuntKayla BetzJennifer F. LaneKeith VogelCharlotte E. HotchkissCassie MoatsAudrey BaldessariRobert D. MurnaneChristopher EnglishCliff A. AstleySolomon WangariBrian AgricolaJoel AhrensNaoto IwayamaAndrew MayLaurence StenslandMeei-Li W. HuangKeith R. JeromeHans-Peter KiemLeslie S. KeanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lucrezia Colonna
Christopher W. Peterson
John B. Schell
Judith M. Carlson
Victor Tkachev
Melanie Brown
Alison Yu
Sowmya Reddy
Willi M. Obenza
Veronica Nelson
Patricia S. Polacino
Heather Mack
Shiu-Lok Hu
Katie Zeleski
Michelle Hoffman
Joe Olvera
Scott N. Furlan
Hengqi Zheng
Agne Taraseviciute
Daniel J. Hunt
Kayla Betz
Jennifer F. Lane
Keith Vogel
Charlotte E. Hotchkiss
Cassie Moats
Audrey Baldessari
Robert D. Murnane
Christopher English
Cliff A. Astley
Solomon Wangari
Brian Agricola
Joel Ahrens
Naoto Iwayama
Andrew May
Laurence Stensland
Meei-Li W. Huang
Keith R. Jerome
Hans-Peter Kiem
Leslie S. Kean
Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation
description Allogeneic hematopoietic cell transplantation (allo-HCT) has led to the cure of HIV in one individual, but the underlying mechanisms are unclear. Here, the authors present a model of allo-HCT in SHIV-infected nonhuman primates and show that the SHIV reservoir persists in multiple tissues early after transplantation.
format article
author Lucrezia Colonna
Christopher W. Peterson
John B. Schell
Judith M. Carlson
Victor Tkachev
Melanie Brown
Alison Yu
Sowmya Reddy
Willi M. Obenza
Veronica Nelson
Patricia S. Polacino
Heather Mack
Shiu-Lok Hu
Katie Zeleski
Michelle Hoffman
Joe Olvera
Scott N. Furlan
Hengqi Zheng
Agne Taraseviciute
Daniel J. Hunt
Kayla Betz
Jennifer F. Lane
Keith Vogel
Charlotte E. Hotchkiss
Cassie Moats
Audrey Baldessari
Robert D. Murnane
Christopher English
Cliff A. Astley
Solomon Wangari
Brian Agricola
Joel Ahrens
Naoto Iwayama
Andrew May
Laurence Stensland
Meei-Li W. Huang
Keith R. Jerome
Hans-Peter Kiem
Leslie S. Kean
author_facet Lucrezia Colonna
Christopher W. Peterson
John B. Schell
Judith M. Carlson
Victor Tkachev
Melanie Brown
Alison Yu
Sowmya Reddy
Willi M. Obenza
Veronica Nelson
Patricia S. Polacino
Heather Mack
Shiu-Lok Hu
Katie Zeleski
Michelle Hoffman
Joe Olvera
Scott N. Furlan
Hengqi Zheng
Agne Taraseviciute
Daniel J. Hunt
Kayla Betz
Jennifer F. Lane
Keith Vogel
Charlotte E. Hotchkiss
Cassie Moats
Audrey Baldessari
Robert D. Murnane
Christopher English
Cliff A. Astley
Solomon Wangari
Brian Agricola
Joel Ahrens
Naoto Iwayama
Andrew May
Laurence Stensland
Meei-Li W. Huang
Keith R. Jerome
Hans-Peter Kiem
Leslie S. Kean
author_sort Lucrezia Colonna
title Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation
title_short Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation
title_full Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation
title_fullStr Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation
title_full_unstemmed Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation
title_sort evidence for persistence of the shiv reservoir early after mhc haploidentical hematopoietic stem cell transplantation
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/4a76aae13cb3419a93e2049fc08cebbe
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