DNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates

Podosomes are protrusive structures that coordinate diverse functions related to cell invasion, migration, bone resorption and immune surveillance. Here the authors integrate DNA nanotechnology with FLIM-FRET to demonstrate that podosomes apply pN integrin tensile forces to sense and respond to subs...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Roxanne Glazier, Joshua M. Brockman, Emily Bartle, Alexa L. Mattheyses, Olivier Destaing, Khalid Salaita
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Q
Acceso en línea:https://doaj.org/article/4a8b99e9937f47cb9e52b7240832a5e8
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:4a8b99e9937f47cb9e52b7240832a5e8
record_format dspace
spelling oai:doaj.org-article:4a8b99e9937f47cb9e52b7240832a5e82021-12-02T17:01:47ZDNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates10.1038/s41467-019-12304-42041-1723https://doaj.org/article/4a8b99e9937f47cb9e52b7240832a5e82019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12304-4https://doaj.org/toc/2041-1723Podosomes are protrusive structures that coordinate diverse functions related to cell invasion, migration, bone resorption and immune surveillance. Here the authors integrate DNA nanotechnology with FLIM-FRET to demonstrate that podosomes apply pN integrin tensile forces to sense and respond to substrate mechanics.Roxanne GlazierJoshua M. BrockmanEmily BartleAlexa L. MattheysesOlivier DestaingKhalid SalaitaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Roxanne Glazier
Joshua M. Brockman
Emily Bartle
Alexa L. Mattheyses
Olivier Destaing
Khalid Salaita
DNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates
description Podosomes are protrusive structures that coordinate diverse functions related to cell invasion, migration, bone resorption and immune surveillance. Here the authors integrate DNA nanotechnology with FLIM-FRET to demonstrate that podosomes apply pN integrin tensile forces to sense and respond to substrate mechanics.
format article
author Roxanne Glazier
Joshua M. Brockman
Emily Bartle
Alexa L. Mattheyses
Olivier Destaing
Khalid Salaita
author_facet Roxanne Glazier
Joshua M. Brockman
Emily Bartle
Alexa L. Mattheyses
Olivier Destaing
Khalid Salaita
author_sort Roxanne Glazier
title DNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates
title_short DNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates
title_full DNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates
title_fullStr DNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates
title_full_unstemmed DNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates
title_sort dna mechanotechnology reveals that integrin receptors apply pn forces in podosomes on fluid substrates
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/4a8b99e9937f47cb9e52b7240832a5e8
work_keys_str_mv AT roxanneglazier dnamechanotechnologyrevealsthatintegrinreceptorsapplypnforcesinpodosomesonfluidsubstrates
AT joshuambrockman dnamechanotechnologyrevealsthatintegrinreceptorsapplypnforcesinpodosomesonfluidsubstrates
AT emilybartle dnamechanotechnologyrevealsthatintegrinreceptorsapplypnforcesinpodosomesonfluidsubstrates
AT alexalmattheyses dnamechanotechnologyrevealsthatintegrinreceptorsapplypnforcesinpodosomesonfluidsubstrates
AT olivierdestaing dnamechanotechnologyrevealsthatintegrinreceptorsapplypnforcesinpodosomesonfluidsubstrates
AT khalidsalaita dnamechanotechnologyrevealsthatintegrinreceptorsapplypnforcesinpodosomesonfluidsubstrates
_version_ 1718382026411737088