DNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates

Podosomes are protrusive structures that coordinate diverse functions related to cell invasion, migration, bone resorption and immune surveillance. Here the authors integrate DNA nanotechnology with FLIM-FRET to demonstrate that podosomes apply pN integrin tensile forces to sense and respond to subs...

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Auteurs principaux:	Roxanne Glazier, Joshua M. Brockman, Emily Bartle, Alexa L. Mattheyses, Olivier Destaing, Khalid Salaita
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/4a8b99e9937f47cb9e52b7240832a5e8
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spelling	oai:doaj.org-article:4a8b99e9937f47cb9e52b7240832a5e82021-12-02T17:01:47ZDNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates10.1038/s41467-019-12304-42041-1723https://doaj.org/article/4a8b99e9937f47cb9e52b7240832a5e82019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12304-4https://doaj.org/toc/2041-1723Podosomes are protrusive structures that coordinate diverse functions related to cell invasion, migration, bone resorption and immune surveillance. Here the authors integrate DNA nanotechnology with FLIM-FRET to demonstrate that podosomes apply pN integrin tensile forces to sense and respond to substrate mechanics.Roxanne GlazierJoshua M. BrockmanEmily BartleAlexa L. MattheysesOlivier DestaingKhalid SalaitaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Roxanne Glazier Joshua M. Brockman Emily Bartle Alexa L. Mattheyses Olivier Destaing Khalid Salaita DNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates
description	Podosomes are protrusive structures that coordinate diverse functions related to cell invasion, migration, bone resorption and immune surveillance. Here the authors integrate DNA nanotechnology with FLIM-FRET to demonstrate that podosomes apply pN integrin tensile forces to sense and respond to substrate mechanics.
format	article
author	Roxanne Glazier Joshua M. Brockman Emily Bartle Alexa L. Mattheyses Olivier Destaing Khalid Salaita
author_facet	Roxanne Glazier Joshua M. Brockman Emily Bartle Alexa L. Mattheyses Olivier Destaing Khalid Salaita
author_sort	Roxanne Glazier
title	DNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates
title_short	DNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates
title_full	DNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates
title_fullStr	DNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates
title_full_unstemmed	DNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates
title_sort	dna mechanotechnology reveals that integrin receptors apply pn forces in podosomes on fluid substrates
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4a8b99e9937f47cb9e52b7240832a5e8
work_keys_str_mv	AT roxanneglazier dnamechanotechnologyrevealsthatintegrinreceptorsapplypnforcesinpodosomesonfluidsubstrates AT joshuambrockman dnamechanotechnologyrevealsthatintegrinreceptorsapplypnforcesinpodosomesonfluidsubstrates AT emilybartle dnamechanotechnologyrevealsthatintegrinreceptorsapplypnforcesinpodosomesonfluidsubstrates AT alexalmattheyses dnamechanotechnologyrevealsthatintegrinreceptorsapplypnforcesinpodosomesonfluidsubstrates AT olivierdestaing dnamechanotechnologyrevealsthatintegrinreceptorsapplypnforcesinpodosomesonfluidsubstrates AT khalidsalaita dnamechanotechnologyrevealsthatintegrinreceptorsapplypnforcesinpodosomesonfluidsubstrates
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DNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates

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