Transcriptional and Post-Transcriptional Polar Effects in Bacterial Gene Deletion Libraries

Single-gene deletion libraries have allowed genome-wide characterization of gene function and interactions. While each mutant intends to disrupt the function of a single gene, it can unintentionally target other genes, such as those located in the same operon as the deletion.

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Autores principales:	André Mateus, Malay Shah, Johannes Hevler, Nils Kurzawa, Jacob Bobonis, Athanasios Typas, Mikhail M. Savitski
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/4ab3295f19b5446c8fc949767b9b3412
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spelling	oai:doaj.org-article:4ab3295f19b5446c8fc949767b9b34122021-12-02T17:48:14ZTranscriptional and Post-Transcriptional Polar Effects in Bacterial Gene Deletion Libraries2379-507710.1128/mSystems.00813-21https://doaj.org/article/4ab3295f19b5446c8fc949767b9b34122021-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00813-21https://doaj.org/toc/2379-5077 Single-gene deletion libraries have allowed genome-wide characterization of gene function and interactions. While each mutant intends to disrupt the function of a single gene, it can unintentionally target other genes, such as those located in the same operon as the deletion.André MateusMalay ShahJohannes HevlerNils KurzawaJacob BobonisAthanasios TypasMikhail M. SavitskiAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmSystems, Vol 6, Iss 5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 André Mateus Malay Shah Johannes Hevler Nils Kurzawa Jacob Bobonis Athanasios Typas Mikhail M. Savitski Transcriptional and Post-Transcriptional Polar Effects in Bacterial Gene Deletion Libraries
description	Single-gene deletion libraries have allowed genome-wide characterization of gene function and interactions. While each mutant intends to disrupt the function of a single gene, it can unintentionally target other genes, such as those located in the same operon as the deletion.
format	article
author	André Mateus Malay Shah Johannes Hevler Nils Kurzawa Jacob Bobonis Athanasios Typas Mikhail M. Savitski
author_facet	André Mateus Malay Shah Johannes Hevler Nils Kurzawa Jacob Bobonis Athanasios Typas Mikhail M. Savitski
author_sort	André Mateus
title	Transcriptional and Post-Transcriptional Polar Effects in Bacterial Gene Deletion Libraries
title_short	Transcriptional and Post-Transcriptional Polar Effects in Bacterial Gene Deletion Libraries
title_full	Transcriptional and Post-Transcriptional Polar Effects in Bacterial Gene Deletion Libraries
title_fullStr	Transcriptional and Post-Transcriptional Polar Effects in Bacterial Gene Deletion Libraries
title_full_unstemmed	Transcriptional and Post-Transcriptional Polar Effects in Bacterial Gene Deletion Libraries
title_sort	transcriptional and post-transcriptional polar effects in bacterial gene deletion libraries
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/4ab3295f19b5446c8fc949767b9b3412
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Transcriptional and Post-Transcriptional Polar Effects in Bacterial Gene Deletion Libraries

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